Skip to main content
Figure 1 | BMC Cancer

Figure 1

From: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

Figure 1

Induction of ATF3 by Hsp90 inhibition in colon cancer in vitro and in vivo. Western blot analysis was performed to determine alterations in ATF3 expression upon inhibition of Hsp90 with 17-DMAG. A) Treatment of human gastric (TMK-1), colon (HT29), or pancreatic (L3.6pl) cancer cells with 17-DMAG (100 nM, 16 h) markedly up-regulated ATF3 in vitro. B) Similarly, in subcutaneous tumor models of gastric (TMK-1), or pancreatic (L3.6pl) cancer, treatment with the Hsp90 inhibitor 17-DMAG (3 × 25 mg/kg/week) up-regulated ATF3 in protein extracts from excised tumors after 14 days.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us