Figure 4From: Mitochondrial targeted catalase suppresses invasive breast cancer in mice Metastatic tumor burden and proliferative capacity are decreased in the presence of mCAT. Surface area of metastatic foci in lungs of PyMT/WT mice (A) was significantly larger than metastatic foci in lungs of PyMT/mCAT mice (B). Arrows indicate metastatic tumors. Original magnification was at 2.5×. C. Ki-67 staining of PyMT metastatic tumor cells negative for mCAT showed a labeling percent of 23. D. Ki-67 staining of PyMT metastatic tumor cells positive for mCAT showed a labeling per cent of 6. The difference in ki-67 labeling between mCAT positive and mCAT negative PyMT metastatic tumor cells was significant at p ≤ 0.01.Back to article page