Figure 2From: MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines Illustrative Fa-CI plot for the combination of Nutlin-3a and Doxorubicin using a 1:1 fixed drug ratio. CI values are calculated from each Fa for the three Nutlin-3a sensitive cell lines in the study. Here we demonstrate average synergism at Fa > 0.5 for T778 whereas OSA and U2OS display average antagonism.Back to article page