Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas

BMC Cancer

Table 2 Clinicopathological variables and their correlation with immunohistochemical expression of HER-2/neu and VEGF

Variable	Patients	HER-2/neu		P-value^a	VEGF		P-value^a
		Positive	Negativ		Positive	Negative
Sex				0.553			0.438
Male	187	29	158		105	82
Female	130	20	110		71	59
Age				0.525			0.817
≤60	195	28	167		107	88
> 60	122	21	101		69	53
Tumor size (cm)				0.004			0.000
< 5 cm	211	23	183		95	111
≥ 5 cm	106	26	85		81	30
Differentiation grade				0.193			0.451
Well	90	10	80		55	35
Moderate	152	23	129		81	71
Poor	75	16	59		40	35
T stage				0.166			0.177
T1~T2	97	11	86		48	49
T3~T4	220	38	182		128	92
Lymph node status				0.460			0.119
Negative	167	25	142		87	80
Positive	150	24	126		89	61
Distant metastasis				0.010^b			0.017
M0	291	40	251		156	135
M1	26	9	17		20	6
Perineural invasion				0.127^b			0.232
Negative	299	44	255		168	131
Positive	18	5	13		8	10

ISSN: 1471-2407