Radiotherapy may improve overall survival of patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter and delay bladder tumour relapse

Table 2 Univariate and multivariate analysis of baseline predictors of survival in 133 patients with transitional cell carcinoma of the renal pelvis and/or ureter

Variables	n	Survival status		pvalue		Correlation with histology
		3-y	5-y	Univariate	Multivariate	coefficient	p
Age						0.130	0.136
< 60 years	31	66.8	66.8	0.029	0.015
≥ 60 years	102	52.5	37.4
Sex						0.136	0.119
Female	50	59.3	48.4	0.402	0.153
Male	83	53.6	35.8
Tumor location						-0.064	0.463
Renal pelvis	42	59.3	59.3	0.912	0.346
Ureter	91	57.0	38.9
Tumor lesions						0.024	0.785
Solitary	117	55.0	42.9	0.612	0.340
Multiple nodules	16	52.9	26.4
pT stage						0.404	< 0.001
T1 or T2	81	76.1	61.6	< 0.001	0.001
T3 or T4	52	22.2	16.7
Synchronous LN						0.143	0.100
-	124	61.7	47.8	< 0.001	0.002
+	9	0	0
Resection modalities						-0.250	0.004
Local resection	22	33.7	33.7	0.024	0.178
Nephroureterectomy	111	63.4	50.0
Residual Disease						0.347	< 0.001
R0	108	65.9	52.2	< 0.001	0.077
R1 or R2	25	10.7	10.7
Histological grade
Grade I or II	79	71.1	56.0	< 0.001	0.465
Grade III or IV	54	33.2	28.4
EBRT						0.116	0.182
No	66	53.6	41.0	0.198	0.024
Yes	67	57.5	49.6

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