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Table 3 Univariate and multivariate predictors of 90 day mortality

From: Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection?

 

Univariate model

Multivariable model (stepwise)

 

Odds Ratios

95% CI

p-value

Odds Ratios

95% CI

p-value

Male

1.42

0.67-3.01

0.36

   

Age ≥ 65 years old

0.54

0.21-1.38

0.21

   

Albumin < 35 g/L

11.73

2.66-51.78

0.01

8.24

1.75-38.81

0.008

LDH > ULN

1.81

0.86-3.79

0.12

   

Metastatic sites > 2

3.01

1.42-6.38

0.01

2.57

1.15-5.72

0.02

ECOG Performance Status > 0

7.40

2.51-21.81

0.01

6.23

2.06-18.83

0.001

Hemoglobin < 12 g/dL

2.47

1.167-5.21

0.02

   

WBC > 10.5 × 10 9 /L

2.59

1.04-6.44

0.04

   

Platelets > 400 × 10 9 /L

0.97

0.31-2.98

0.95

   

Lymphocytes < 0.7 × 10 9 /L

2.21

0.94-5.23

0.07

   

Lung metastases

2.04

0.92-4.51

0.08

   

Liver metastases

2.04

0.94-4.43

0.07

   

Bone metastases

1.41

0.57-3.53

0.46

   

Brain metastases

6.22

0.38-101.94

0.22

   

Lymph node metastases

2.16

1.02-4.54

0.04

   

Peritoneal metastases

0.76

0.28-2.10

0.60

   

Prior treatments ≥ 3

0.76

0.35-1.64

0.48

   
  1. Abbreviations: LDH = lactate dehydrogenase; ULN = upper limit of normal; ECOG = Eastern Cooperative Oncology Group; WBC = white blood cells; CI = confidence interval