Worst toxicity severity grade of haematological toxicity by patient (number of patients (%)) | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose level | 135 mg/m2 | 270 mg/m2 | 540 mg/m2 | 675 mg/m2 | 900 mg/m2 | All doses | ||||||||||||
Number of patients | n = 3 | n = 6 | n = 6 | n = 7 | n = 4 | n = 26 | ||||||||||||
Toxicity severity grade | 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 4 | 2 | 3 | 4 |
Anaemia | 1 (33) | 1 (33) | Â | 2 (33) | 1 (17) | Â | 4 (67) | 1 (17) | Â | 4 (57) | 1 (14) | 1 (14) | 2 (50) | 2 (50) | Â | 13 (50) | 6 (23) | 1 (14) |
Leukopenia | Â | Â | Â | 1 (17) | Â | Â | 2 (33) | 1 (17) | Â | 3 (43) | 2 (29) | Â | 2 (50) | 1 (25) | Â | 8 (31) | 4 (15) | Â |
Neutropenia | Â | Â | Â | 1 (17) | Â | Â | 2 (33) | 1 (17) | Â | 2 (29) | 1 (14) | Â | Â | Â | 3 (75) | 5 (19) | 2 (8) | 3 (12) |
Thrombocytopenia | Â | Â | Â | 1 (17) | Â | Â | 1 (17) | 1 (17) | 1 (17) | 1 (14) | 2 (29) | Â | Â | 1 (25) | 2 (50) | 3 (12) | 4 (15) | 2 (8) |
Any haematological toxicity | 1 (33) | 1 (33) | Â | 3 (50) | 1 (17) | Â | 3 (50) | 2 (33) | 1 (17) | 4 (57) | 2 (29) | 1 (14) | Â | Â | 4 (100) | 11 (42) | 6 (23) | 6 (23) |