Table 1 Chemotherapic agents used in the present study
From: Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines
Clinical dose | Half time | In vivo AUC72 hr | In vitro used concentrations | In vitro AUC72 hr | Ref | QAUC | |||
|---|---|---|---|---|---|---|---|---|---|
Antimetabolites | Folic acid | Methotrexate | 12 g/m2 | 24 | 623,70 | 0,033 - 4,17 | 12,000-1499,976 | [21] | 0,019 - 2,405 |
Purine | Cladribine | 5 mg/m2 | 3 | 5,67 | 0,007 - 0,83 | 0,480-59,976 | [22] | 0,085-10,578 | |
Fludarabine | 25 mg/m2 | 2 | 27,72 | 0,167 - 20,83 | 12,000-1499,976 | [23] | 0,433-54,112 | ||
6-Mercaptopurin | 85 mg/m2 | 4 | 138,60 | 0,556 - 69,44 | 39,997-4999,680 | [24] | 0,289-36,073 | ||
Pyrimidine | Cytarabine | 1 g/m2 | 2 | 221,76 | 0,133 - 16,66 | 9,596-1199,520 | [25] | 0,043-5,409 | |
Fluorouracil | 400 mg/m2 | 0.25 | 69,30 | 0,333 - 41,66 | 23,996-2999,520 | [26] | 0,346-43,283 | ||
Gemcitabine | 1000 mg/m2 | 0.7 | 388,08 | 0,267 - 33,33 | 19,198-2399,760 | [27] | 0,049-6,184 | ||
Alkylating/alkylating-like | Nitrogen mustards | Chlorambucil | 0.2 mg/m2 | 2 | 33,60 | 0,667 - 83,33 | 47,998-5999,760 | [28] | 1,429-178,564 |
Platinum | Carboplatin | 360 mg/m2 | 3 | 665,28 | 0,007 - 0,83 | 0,480-59,976 | [29] | 0,001-0,090 | |
Oxaliplatin | 130 mg/m2 | 5.74 | 270,46 | 0,033 - 4,17 | 2,400-299,952 | [30] | 0,009-1,109 | ||
Spindle poison/mitotic inhibitor | Taxane | Docetaxel | 85 mg/m2 | 0.6 | 24,95 | 0,067 - 8,33 | 4,798-599,760 | [31] | 0,192-24,040 |
Paclitaxel | 175 mg/m2 | 3 | 257,80 | 0,013 - 1,67 | 0,956-119,520 | [27] | 0,004-0,464 | ||
Vinca | Vinblastin | 1.7 mg/m2 | 0.83 | 1,71 | 0,00067 - 0,083 | 0,048-5,998 | [32] | 0,028-3,510 | |
Vincristine | 1.32 mg/m2 | 2 | 1,55 | 0,00067 - 0,083 | 0,480-59,976 | [33] | 0,309-38,636 | ||
Vinorelbine | 80 mg/m2 | 40 | 498,96 | 0,007 - 0,83 | 4,798-599,760 | [34] | 0,010-1,202 | ||
Cytotoxic/antitumor antibiotics | Anthracyclin | Daunorubicin | 1.5 mg/kg | 18 | 531,56 | 0,033 - 4,17 | 2,400-299,952 | [35] | 0,005-0,564 |
Doxorubicin | 50 mg/m2 | 30 | 1091,48 | 0,013 - 1,66 | 0,956-119,520 | [36] | 0,001-0,110 | ||
Epirubicin | 90 mg/m2 | 15 | 604,21 | 0,013 - 1,66 | 0,960-119,952 | [27] | 0,002-0,199 | ||
Streptomyces | Dactinomycin | 1.5 mg/m2 | 36 | 8,98 | 0,003 - 0,42 | 0,240-29,995 | [37] | 0,027-3,340 | |
Bleomycin | 8 IU/kg/day | 6 | 33,26 | 0,008 - 1 | 0,576-72,000 | [38] | 0,017-2,165 | ||
Mitomycin | 20 mg/m2 | 1 | 4,44 | 0,003 - 0,33 | 0,317-39,600 | [39] | 0,071-8,929 | ||
Hydroxyurea | 15 mg/m2 | 2 | 630,00 | 0,333 - 41,66 | 23,996-2999,520 | [40] | 0,038-4,761 | ||
Topo-isomerase in-hibitors | Camptotheca | Topotecan | 1.2 mg/m2 | 3 | 2,49 | 0,007 - 0,83 | 0,054-6,718 | [41] | 0,022-2,693 |
Etoposide | 100 mg/m2 | 4 | 221,76 | 0,133 - 16,66 | 9,596-1199,520 | [25] | 0,043-5,409 | ||
Other | Asparaginase | 30000 IU/m2 | 8 | 26,56 | 0,033 - 4,17 | 2,400-299,952 | [42] | 0,090-11,294 | |
Bortezomib | 1.45 mg/m2 | 40 | 21,62 | 0,007 - 0,83 | 0,480-59,976 | [43] | 0,022-2,774 | ||
Prednisolone | 1 mg/kg/day | 3 | 41.58 | 0,16666 - 20,83 | 11,998-1499,760 | [44] | 0,289-36,069 |