Clinicopathologic and gene expression parameters predict liver cancer prognosis

BMC Cancer

Table 2 Using Independent HCC Studies to Validate HKU Gene Signature Identified at 0.05 Level

HKU Gene Signature in Normal Tissue
	Survival (7400 HKU Gene Signature) ^‡
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	92	1.1E-9
Chinese-Belgium Gene Signature	133	3.1E-14
Asia HCC Metastases Gene Signature	144	2.0E-9
Singapore Gene Signature	19	2.4E-2
	Disease Free Survival (7661 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	96	1.8E-10
Chinese-Belgium Gene Signature	131	3.6E-12
Asia HCC Metastases Gene Signature	145	1.3E-8
Singapore Gene Signature	21	7.6E-3
HKU Gene Signature in Tumor Tissue
	Survival (5403 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	66	2.4E-6
Chinese-Belgium Gene Signature	142	5.5E-33
Asia HCC Metastases Gene Signature	97	1.2E-4
Singapore Gene Signature	19	4.9E-4
	Disease Free Survival (4377 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	58	9.1E-7
Chinese-Belgium Gene Signature	131	1.7E-35
Asia HCC Metastases Gene Signature	89	1.9E-6
Singapore Gene Signature	15	2.8E-3

^‡We selected genes associated with survival or disease-free survival using nominal p-value of 0.05.

ISSN: 1471-2407