Figure 4
From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events
A subset of genes is commonly suppressed by BCR-ABL, TEL-PDGFRB and TEL-JAK2. Genes induced or suppressed by BCR-ABL, TEL-PDGFRB and TEL-JAK2 by 2-fold or greater were identified. Fold-suppressions of gene expression are indicated in the table (Bottom) and are displayed in a bar-graph (Top). Asterisks denote genes that were validated by Q-PCR. Pdcd4, programmed cell death 4; Gadd45a, growth arrest and DNA-damage-inducible 45a; Col5a1, procollagen, type V, alpha1; Lamb1, laminin B1 subunit; Myb, myeloblastosis oncogene; Pik3c2g, PI3-kinase, C2 domain containing gamma polypeptide; Hdac7, histone deacetylase 7; Cyp26a1, Cytochrome P450, family 26, subfamily a, polypeptide 1; H2bfs, H2B histone family, member 2; Ttyh2, tweety homolog 2; Scin, scinderin.