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Figure 2 | BMC Cancer

Figure 2

From: Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

Figure 2

Characterization and comparison of rGel-based fusion toxins. A. Evaluation of the binding of the fusion constructs CPE-G4S-rGel (solid up-side-down triangle), CPE-R9-rGel (solid circle), CPE-E9-G4S-R9-rGel (solid upright triangle) and rGel (open square) to 2008 cells by whole-cell ELISA. B. Evaluation of the binding of the fusion constructs CPE-G4S-rGel (solid up-side-down triangle), CPE-R9-rGel (solid circle), CPE-E9-G4S-R9-rGel (solid upright triangle) and rGel (open square) to 2008-CLDN3KD-4.5 cells by whole-cell ELISA. C. The enzymatic (N-glycosidase) activity of the rGel component of the fusions (solid sqaure, rGel; solid upright triangle, CPE-G4S-rGel; solid circle, CPE-R9-rGel; open square, R9-rGel; open upright triangle, E9-G4S-R9-rGel; open up-side-down triangle, CPE-E9-G4S-R9-rGel) as assessed using rabbit reticulocyte lysate assay.

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BMC Cancer

ISSN: 1471-2407

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