Figure 3

Photomicrographs showing spindle cells with areas of hypercellularity or necrosis. (A) Low-power view of the area with spindle cells proliferation (Hematoxylin and Eosin (HE) double stain, × 40). (B) Spindle cells with positive reactivity for α-smooth muscle actin (SMA) comprise approximately 30% area of the tumor (Immunostain, anti-α-SMA × 40). (C) There is focus of necrosis in the limited the tumor. Following to the French National Federation of Cancer grading system, presence of tumor necrosis less than half in area corresponds to score-1 (HE double stain, × 100). (D) Spindle cells showed mitosis. On average, twelve mitoses per ten high-power fields were confirmed. Following to the French National Federation of Cancer grading system, mitotic activity of the present case corresponds to score-2 (HE double stain, × 1000).