Table 3 Characteristics and clinical data of 721 NSCLC and 150 SCLC patients of CAPUA study
From: Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival
Variables | NSCLC | SCLC | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Deaths | MST (months) | Log-rank | HR | 95% CI | Patients | Deaths | MST (months) | Log-rank | HR | 95% CI | |||
n | % | n | % | |||||||||||
Gender | 0.293 | 0.053 | ||||||||||||
Male | 643 | 89.2 | 598 | 9.3 | 1.00 | 134 | 89.3 | 123 | 8.3 | 1.00 | ||||
Female | 78 | 10.8 | 68 | 12.5 | 0.87 | 0.68-1.12 | 16 | 10.7 | 14 | 14.5 | 0.57 | 0.32-1.02 | ||
Age (years) | 0.083 | 0.041 | ||||||||||||
≤ 68 | 375 | 52.0 | 342 | 11.3 | 1.00 | 79 | 52.7 | 69 | 9.8 | 1.00 | ||||
> 68 | 346 | 48.0 | 324 | 8.2 | 1.15 | 0.98-1.34 | 71 | 47.3 | 68 | 7.6 | 1.42 | 1.01-2.00 | ||
Smoking Status | 0.585 | 0.025 | ||||||||||||
Never | 45 | 6.3 | 41 | 10.5 | 1.00 | 7 | 4.7 | 6 | 54.2 | 1.00 | ||||
Ever | 672 | 93.7 | 621 | 9.5 | 0.92 | 0.67-1.26 | 142 | 95.3 | 130 | 8.4 | 2.51 | 1.09-5.75 | ||
Former | 307 | 45.8 | 284 | 9.4 | 0.809 | 0.90 | 0.65-1.25 | 59 | 41.8 | 54 | 7.5 | 0.022 | 2.88 | 1.29-6.43 |
Current | 363 | 54.2 | 335 | 9.5 | 0.93 | 0.67-1.28 | 82 | 58.2 | 75 | 9.2 | 2.24 | 1.02-4.91 | ||
Histological Types | 0.608 | |||||||||||||
Squamous cell carcinoma | 358 | 49.6 | 335 | 10.9 | 1.00 | |||||||||
Adenocarcinoma | 264 | 36.6 | 240 | 10.2 | 1.05 | 0.89-1.24 | ||||||||
Others | 99 | 13.7 | 91 | 7.8 | 1.12 | 0.89-1.43 | ||||||||
Clinical stages | 0.000 | |||||||||||||
I | 186 | 26.1 | 151 | 26.1 | 1.00 | 0.000 | ||||||||
II | 58 | 8.1 | 51 | 19.7 | 1.45 | 1.05-2.00 | ||||||||
III | 244 | 34.3 | 238 | 9.6 | 2.26 | 1.83-2.79 | ||||||||
IV | 224 | 31.5 | 220 | 5.2 | 3.97 | 3.19-4.94 | ||||||||
Limited stage (LS) | 78 | 52.3 | 69 | 12.2 | 1.00 | |||||||||
Extend stage (ES) | 71 | 47.7 | 67 | 5.8 | 2.19 | 1.54-3.11 | ||||||||
Surgical Operation | 0.000 | |||||||||||||
None | 523 | 72.5 | 509 | 7.2 | 1.00 | |||||||||
Yes | 198 | 27.5 | 157 | 30.9 | 0.32 | 0.27-0.39 | ||||||||
Chemo or Radiotherapy | 0.469 | |||||||||||||
None | 301 | 41.7 | 262 | 6.9 | 1.00 | |||||||||
Yes | 420 | 58.3 | 412 | 11.7 | 1.06 | 0.90-1.24 | ||||||||
Chemotherapy | 0.000 | |||||||||||||
None | 29 | 19.3 | 28 | 1.6 | 1.00 | |||||||||
Yes | 121 | 80.7 | 109 | 9.9 | 0.41 | 0.26-0.62 | ||||||||
Radiotherapy | 0.000 | |||||||||||||
None | 74 | 49.3 | 71 | 5.4 | 1.00 | |||||||||
Yes | 76 | 50.7 | 66 | 12.1 | 0.46 | 0.32-0.64 | ||||||||