Figure 7
Effects of JS-K on the proliferation of prostate cancer cells. (A) 22Rv1 cells are more susceptible to the growth inhibitory effects of JS-K than the androgen sensitive LNCaP cells Cells were cultured in the absence/presence of increasing concentrations of JS-K (1,2,4 μM) or JS-Kneg (4 μM). Cell viability was determined after 96 hours by a colorimetric MTT assay. Results are mean values of four independent experiments performed in quadruplicates. Data are presented as % of untreated controls ± SD, *p < 0.05. (B) Effects of JS-K on the AR negative DU-145 and the AR-positive LNCaP (hormone sensitive) and LNCaP-SSR (castration resistant). Cells were cultured in the absence/presence of increasing concentrations of JS-K (1, 2, 4 μM) or JS-Kneg (4 μM). Cell viability was determined after 96 hours by a colorimetric MTT assay. Results are mean values of four independent experiments performed in quadruplicates.