Characteristic | Pre-menopausal women (n = 109) | Post-menopausal women (n = 389) | ρ value† | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Low risk* | Intermediate risk* | High risk* | Overall | Low risk* | Intermediate risk* | High risk* | Overall | |||
(n = 11) | (n = 78) | (n = 20) | (n = 109) | (n = 115) | (n = 196) | (n = 78) | (n = 389) | |||
Age ( years) | ||||||||||
Mean (range) | 41.8 | 43.6 | 42.7 | 43 | 63.4 | 64 | 61.8 | 63 | ||
(30 – 49) | (29 – 49) | (33–49) | (29–49) | (50–85) | (50 – 88) | (50–86) | (50–88) | |||
<40 | 3 (27.3) | 17 (21.8) | 4 (20) | 24 (22) | ― | ― | ― | ― | ||
40 – 49 | 8 (72.7) | 61 (78.2) | 16 (80) | 85 (78) | ― | ― | ― | ― | ||
50 – 64 | ― | ― | ― | ― | 64 (55.7) | 111 (56.6) | 53 (68) | 228 (58.6) | ||
≥65 | ― | ― | ― | ― | 51 (44.3) | 85 (43.4) | 25 (32) | 161 (41.4) | ||
Primary tumour size – no. of women (%) | ||||||||||
<2 cm | 11 (100) | 51 (65.4) | 7 (35) | 69 (63.3) | 115 (100) | 117 (59.7) | 17 (21.8) | 260 (66.8) | .78 | |
2-5 cm | 0 | 27 (34.6) | 11 (55) | 38 (34.9) | 0 | 79 (40.3) | 55 (70.5) | 123 (31.7) | ||
>5 cm | 0 | 0 | 2 (10) | 2 (1.8) | 0 | 0 | 6 (7.7) | 6 (1.5) | ||
Receptor status – no. of women (%) | ||||||||||
ER + and PR- | 0 | 11 (14.1) | 7 (35) | 18 (16.6) | 25 (21.7) | 54 (27.5) | 30 (38.5) | 109 (28) | .016 | |
ER- and PR+ | 0 | 4 (5.2) | 3 (15) | 7 (6.4) | 1 (0.9) | 4 (2.1) | 6 (7.7) | 11 (2.8) | ||
ER + and PR+ | 11 (100) | 63 (80.7) | 10 (50) | 84 (77) | 89 (77.4) | 138 (70.4) | 42 (53.8) | 269 (69.2) | ||
Tumour grade – no. of women (%) | ||||||||||
1 | 6 (54.5) | 14 (18) | 1 (5) | 21 (19.3) | 89 (77.4) | 17 (8.7) | 1(1.3) | 107 (27.5) | .37 | |
2 | 0 | 50 (64.1) | 5 (25) | 55 (50.5) | 0 | 160 (81.6) | 21 (26.9) | 181 (46.5) | ||
3 | 0 | 5 (6.4) | 14 (70) | 19 (17.4) | 0 | 6 (3) | 53 (68) | 59 (15.2) | ||
Unknown | 5 (45.5) | 9 (11.5) | 0 | 14 (12.8) | 26 (22.6) | 13 (6.7) | 3 (3.8) | 42 (10.8) | ||
Stage | ||||||||||
I | 11 (100) | 55 (70.5) | 7 (35) | 73 (67) | 115 (100) | 145 (74) | 21 (26.9) | 281 (72.2) | .56 | |
IIA | 0 | 23 (29.5) | 11 (55) | 34 (31.2) | 0 | 51 (26) | 51 (65.4) | 102 (26.2) | ||
IIB | 0 | 0 | 2 (10) | 2 (1.8) | 0 | 0 | 6 (7.7) | 6 (1.6) | ||
With Breast-surgery‡ − no. of women (%) | 11 (100) | 78 (100) | 20 (100) | 109 (100) | 115 (100) | 196 (100) | 78 (100) | 389 (100) | ||
Breast-conserving surgery | 8 (72.7) | 51 (65.4) | 9 (45) | 68 (62.4) | 65 (56.5) | 113 (57.7) | 29 (37.2) | 207 (53.4) | .08 | |
Mastectomy | 3 (27.3) | 27 (34.6) | 11 (55) | 41 (37.6) | 50 (43.5) | 83 (42.3) | 49 (62.8) | 182 (46.6) | ||
With Radiotherapy‡ − no. of women (%) | 7 (63.6) | 51 (65.4) | 11 (55) | 69 (63.3) | 62 (54) | 109 (55.6) | 30 (38.5) | 201 (51.7) | .03 | |
With Endocrine therapy‡ − no. of women (%) | 5 (45.4) | 65 (83.3) | 18 (90) | 88 (81) | 91 (79.1) | 165 (84.1) | 53 (67.9) | 309 (79.4) | .76 | |
Tamoxifen | 5 (100) | 49 (75.4) | 13 (72) | 67 (76.1) | 61 (67) | 104 (63) | 31 (58.5) | 196 (63.4) | .02 | |
Aromatase inhibitors + tamoxifen | 0 | 13 (20) | 4 (22) | 17 (19.3) | 25 (27.5) | 48 (29) | 18 (34) | 91 (29.5) | ||
Aromatase inhibitors | 0 | 1 (1.5) | 0 | 1 (1.2) | 5 (5.5) | 10 (6) | 3 (5.7) | 18 (5.8) | ||
Unknown type | 0 | 2 (3) | 1 (5.5) | 3 (3.4) | 0 | 3 (2) | 1 (1.8) | 4 (1.3) | ||
With adjuvant chemotherapy‡ − no. of women (%) | 3 (27.3) | 51 (65.4) | 20 (100) | 74 (69) | 3 (2.6) | 28 (14.3) | 42 (53.8) | 73 (18.8) | <.0001 | |
No anthracyclines | 0 | 17 (33.3) | 5 (25) | 22 (35.6) | 1 | 9 (32.1) | 16 (38.1) | 26 (29.7) | .88 | |
Anthracyclines, no taxanes | 3 (100) | 29 (56.9) | 12 (60) | 44 (54.8) | 1 | 16 (57.1) | 23 (54.8) | 40 (59.5) | ||
Anthracyclines and taxanes | 0 | 2 (3.9) | 2 (10) | 4 (4.1) | 0 | 0 | 3 (7.1) | 3 (5.4) | ||
Unkown type | 0 | 3 (5.9) | 1 (5) | 4 (5.5) | 1 | 3 (10.8) | 0 | 4 (5.4) | ||
Loco-regional recurrence event – no. of women (%) | 0 | 4 (5.1) | 2 (10) | 7 (6.4) | 1 (.86) | 2 (1) | 10 (12.8) | 13 (3.3) | .14 | |
Distant recurrence event – no. of women (%) | 0 | 3 (3.8) | 3 (15) | 6 (5.5) | 2 (1.7) | 10 (5.1) | 14 (17.9) | 26 (6.7) | .65 | |
Deaths – no. of women (%) | 0 | 3 (3.8) | 3 (15) | 6 (5.5) | 10 (8.6) | 31 (15.8) | 22 (28.2) | 63 (16.2) | .004 | |
Charlson co-morbidity score mean (SE, range) | 0 | 0.10 | 0.05 | 0.08 | 0.11 | 0.20 | 0.19 | 0.18 | .028 | |
(0.03, 0–2) | (0.03, 0–6) | |||||||||
Charlson co-morbidity score – no. of women (%) | ||||||||||
0 | 11 (100) | 71 (91) | 19 (95) | 101(92.6) | 104 (90.4) | 171 (87.3) | 69 (88.4) | 344 (88.4) | .86 | |
1 | 0 | 6 (7.7) | 1 (5) | 7 (6.4) | 9 (7.8) | 18 (9.2) | 6 (7.7) | 33 (8.4) | ||
2 | 0 | 1 (1.3) | 0 | 1 (1) | 2 (1.8) | 3 (1.5) | 1 (1.3) | 6 (1.5) | ||
3 | 0 | 0 | 0 | 0 | 0 | 2 (1) | 1 (1.3) | 3 (.8) | ||
4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.3) | 1 (.3) | ||
5 | 0 | 0 | 0 | 0 | 0 | 1 (.5) | 0 | 1 (.3) | ||
6 | 0 | 0 | 0 | 0 | 0 | 1 (.5) | 0 | 1 (.3) |