HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

Table 1 Correlations between HuR and cyclin A expression and other important clinicopathological parameters

Parameter		No. of cases	HuR Cyto. Exp.^†		pvalue	Cyclin A Exp.		pvalue
Parameter		No. of cases	Low	High	pvalue	Low	High	pvalue
Gender	Male	182	93	89	0.664	85	95	0.384
Gender	Female	158	77	81		83	75
Age (years)	<65	138	72	66	0.508	75	63	0.185
Age (years)	≥65	202	98	104		95	107
Tumor side	Right	177	96	81	0.201	89	88	0.931
	Left	154	71	83		76	78
	Bilateral	9	3	6		5	4
Tumor location	Renal pelvis	141	76	65	0.374	66	75	0.607
	Ureter	150	73	77		78	72
	Renal pelvis and ureter	49	21	28		26	23
Multifocality	Single	278	143	135	0.261	140	138	0.779
Multifocality	Multifocal	62	27	35		30	32
Primary tumor (T)	Ta ~ T1	181	109	72	<0.001*	104	77	0.003*
Primary tumor (T)	T2 ~ T4	159	61	98		66	93
Nodal metastasis	Negative (N0)	312	166	146	<0.001*	159	153	0.237
Nodal metastasis	Positive (N1 ~ N2)	28	4	24		11	17
Histological grade	Low grade	56	37	19	0.008*	39	17	0.001*
Histological grade	High grade	284	133	151		131	151
Pattern of invasion	Non-invasive/Nodular	200	112	88	0.030*	108	92	0.191
	Trabecular	58	24	34		27	31
	Infiltrative	82	34	48		35	47
Vascular invasion	Absent	234	126	108	0.035*	124	110	0.101
Vascular invasion	Present	106	44	62		46	60
Perineurial invasion	Absent	321	166	155	0.009*	162	159	0.479
Perineurial invasion	Present	19	4	15		8	11
Mitotic rate (per 10 high power fields)	<10	173	89	84	0.588	103	70	<0.001*
Mitotic rate (per 10 high power fields)	≥10	167	81	86		67	100
Cyclin A expression	Low	164	95	69	0.005*	-	-	-
Cyclin A expression	High	176	75	101		-	-

ISSN: 1471-2407