Variable | Category | Disease-specific survival | Metastasis-free survival | UB Recurrence-free survival | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Relative risk | 95% Confidence interval | pvalue | Relative risk | 95% Confidence interval | pvalue | Relative risk | 95% Confidence interval | pvalue | ||
Nodal metastasis | Positive vs. negative | 5.602 | 2.912 ~ 10.776 | <0.001* | 3.174 | 1.648 ~ 6.115 | 0.001* | - | - | - |
Perineurial invasion | Present vs. absent | 3.291 | 1.522 ~ 7.117 | 0.002* | 2.460 | 1.120 ~ 5.401 | 0.025* | - | - | - |
Multifocality | Multifocal vs. single | 2.816 | 1.321 ~ 6.004 | 0.007* | 2.408 | 1.124 ~ 5.158 | 0.024* | - | - | - |
Pattern of invasion | Infiltrative vs. trabecular vs. non-invasive/Nodular | 1.596 | 1.090 ~ 2.337 | 0.016* | 1.307 | 0.906 ~ 1.885 | 0.152 | - | - | - |
Histological grade | High grade vs. low grade | 3.751 | 1.170 ~ 12.024 | 0.026* | 4.187 | 1.221 ~ 14.364 | 0.023* | 2.113 | 1.173-3.805 | 0.013* |
HuR Cyto. Exp.†| High vs. low | 1.996 | 1.039 ~ 3.834 | 0.038* | 1.880 | 1.074 ~ 3.291 | 0.027* | 1.398 | 0.886-2.204 | 0.150 |
Vascular invasion | Present vs. absent | 1.549 | 0.823 ~ 2.913 | 0.175 | 2.872 | 1.486 ~ 5.550 | 0.002* | - | - | - |
Cyclin A expression | High vs. low | 1.632 | 0.909 ~ 2.932 | 0.101 | 1.703 | 0.994 ~ 2.918 | 0.053 | - | - | - |
Primary tumor (T) | T2 ~ T4 vs. Ta ~ T1 | 1.412 | 0.586 ~ 3.400 | 0.442 | 0.916 | 0.419 ~ 2.003 | 0.826 | - | - | - |
Tumor location | Both renal pelvis and ureter vs. one location alone | 0.950 | 0.614 ~ 1.471 | 0.819 | 0.786 | 0.572 ~ 1.340 | 0.541 | - | - | - |
Mitotic rate | ≥10 vs. <10/10 hpf | - | - | - | 0.849 | 0.514 ~ 1.402 | 0.523 | - | - | - |
Gender | Male vs. female | - | - | - | - | - | - | 1.607 | 1.030-2.507 | 0.036* |