Table 4 Sensitivity and specificity within the ≥ 5%, ≥ 10%, ≥ 20% and ≥ 30% thresholds of the risk prediction models for the MMR germline mutation
Models and threshold | Sensitivity | Specificity |
|---|---|---|
MMRpro | Â | Â |
≥ 5% | 1.00 | 0.03 |
≥ 10% | 0.96 | 0.08 |
≥ 20% | 0.90 | 0.38 |
≥ 30% | 0.87 | 0.52 |
MMRPredict | Â | Â |
≥ 5% | 0.93 | 0.38 |
≥ 10% | 0.90 | 0.33 |
≥ 20% | 0.83 | 0.70 |
≥ 30% | 0.80 | 0.75 |
Myriad | Â | Â |
≥ 5% | 1.00 | 0 |
≥ 10% | 0.94 | 0.31 |
≥ 20% | 0.74 | 0.56 |
≥ 30% | 0.10 | 0.92 |
PREMM | Â | Â |
≥ 5% | 0.98 | 0.28 |
≥ 10% | 0.90 | 0.54 |
≥ 20% | 0.67 | 0.85 |
≥ 30% | 0.67 | 0.85 |
Wijnen | Â | Â |
≥ 5% | 1.00 | 0 |
≥ 10% | 0.94 | 0.31 |
≥ 20% | 0.74 | 0.56 |
≥ 30% | 0.10 | 0.92 |