Table 1 Clinico-laboratory characteristics in AML patients with NPM1 mutations

Age^#

0.001

 Adult(>18 years)

491

106(21.6)

385(78.4)

 Children

52

2(3.8)

50(96.2)

Gender^#

0.007

 Male

315

50(15.9)

265(84.1)

 Female

228

58(25.4)

170(74.6)

Laboratory data

 WBC(uL)

20660

38860

14260

0.002

 Hemoglobin (g/dL)

8.1

8.4

8.0

0.095

 Platelet(uL)

43000

52000

40000

0.865

 LDH (units/L)

861

1068

826

0.149

FAB subtype^#

0.008

 M0

10

0(0)

10(100)

 M1

120

23(19.2)

97(80.8)

 M2

184

40(21.7)

144(78.3)

 M3

40

0(0)

40(100)

 M4

131

34(26.0)

97(74.0)

 M5

33

10(30.3)

23(69.7)

 M6

11

1(9.1)

10(90.9)

 M7

3

0(0)

3(100)

 Undetermined

5

0(0)

5(100)

Cytogenetic^#*

<0.001

 Normal karyotype

241

90(37.3)

151(62.7)

 Abnormal karyotype

283

13(4.6)

270(95.4)

Immunophenotype**

 HLA-DR

364/515

50/105(47.6)

314/410(76.6)

<0.001

 CD7

100/511

16/104(15.4)

84/407(20.6)

0.269

 CD13

481/519

96/105(91.4)

385/414(93.0)

0.536

 CD14

70/503

18/104(17.3)

52/399(13.0)

0.267

 CD15

237/511

46/104(44.2)

191/407(46.9)

0.660

 CD33

472/518

105/105(100)

367/413(88.9)

<0.001

 CD34

328/514

22/104(21.1)

306/410(74.6)

<0.001

 CD56

109/457

19/95(20.0)

90/362(24.9)

0.347