IGF1R expression | IGFBP3 expression | Both IGF1R (+) and IGFBP3 (−) | |||||||
---|---|---|---|---|---|---|---|---|---|
Characteristics | positive | negative | positive | negative | positive | others | |||
n = 50 | n = 72 | p-value | n = 37 | n = 85 | p-value | n = 32 | n = 90 | p-value | |
Age | |||||||||
   <60 | 7 | 18 | 10 | 15 | 3 | 22 | |||
   ≧60 | 43 | 54 | 0.139 | 27 | 70 | 0.238 | 29 | 68 | 0.07 |
Gender | |||||||||
   Male | 25 | 31 | 15 | 41 | 16 | 40 | |||
   Female | 25 | 41 | 0.449 | 22 | 44 | 0.433 | 16 | 50 | 0.588 |
T category | |||||||||
   T1, T2 | 9 | 17 | 7 | 19 | 3 | 23 | |||
   T3, T4 | 41 | 55 | 0.457 | 30 | 66 | 0.670 | 29 | 67 | |
N category | 0.077 | ||||||||
   N0 | 23 | 33 | 20 | 36 | 14 | 42 | |||
   N1 | 27 | 39 | 0.986 | 17 | 49 | 0.233 | 18 | 48 | 0.776 |
Stage | |||||||||
   I | 4 | 11 | 5 | 10 | 0 | 15 | |||
   II & III | 46 | 61 | 32 | 75 | 32 | 75 | |||
Tumor location | 0.273 | 0.787 | 0.011 | ||||||
   proximal | 31 | 50 | 30 | 51 | 18 | 63 | |||
   distal | 19 | 22 | 7 | 34 | 14 | 27 | |||
Tumor differentiation | 0.392 | 0.023 | 0.157 | ||||||
   Grade1, 2 | 46 | 56 | 34 | 68 | 28 | 74 | |||
   Grade 3, 4 | 4 | 16 | 0.037 | 3 | 17 | 0.082 | 4 | 16 | 0.588 |
Lymphatic invasion | |||||||||
   negative | 24 | 42 | 19 | 47 | 15 | 51 | |||
   positive | 26 | 30 | 0.260 | 18 | 38 | 0.688 | 17 | 39 | 0.340 |
Arterial invasion | |||||||||
   negative | 43 | 67 | 33 | 77 | 27 | 83 | |||
   positive | 7 | 5 | 0.198 | 4 | 8 | 0.754 | 5 | 7 | 0.200 |
Venous invasion | |||||||||
   negative | 45 | 62 | 36 | 71 | 28 | 79 | |||
   positive | 5 | 10 | 0.52 | 1 | 14 | 0.037 | 4 | 11 | 0.967 |
Intrapancreatic nerve invasion | |||||||||
   negative | 21 | 38 | 16 | 43 | 16 | 43 | |||
   positive | 29 | 34 | 0.241 | 21 | 42 | 0.456 | 16 | 47 | 0.829 |
Tumor stromal volume | |||||||||
   med & int | 31 | 55 | 27 | 59 | 19 | 67 | |||
   sci | 19 | 17 | 0.087 | 10 | 26 | 0.692 | 13 | 23 | 0.108 |
IGFBP3 expression | |||||||||
   negative | 32 | 53 | |||||||
   positive | 18 | 19 | 0.256 |