Table 3 Association between NLR, clinical and pathology features and overall survival
| Â | Number of patients | Number of deaths | Bivariate association HR, (95% CI), Wald p | Multivariable association HR, (95% CI), Wald p |
|---|---|---|---|---|
Neutrophil/lymphocyte ratio | 322 | 141 | 1.11 (1.06–1.15) p < 0.001 | 1.06 (1.01–1.12) p= 0.013 |
Male | 179 | 79 | 1.04 (0.74–1.45) p = 0.831 | -- |
Female | 143 | 62 | ||
Age ≥ 75 years | 108 | 75 | 3.32 (2.37–4.63) p < 0.001 | 2.15 (1.42–3.27) p < 0.001 |
Age < 75 years | 214 | 66 | ||
Rectal tumor | 127 | 54 | 0.88 (0.62–1.23) p = 0.446 | -- |
Colonic tumor | 195 | 87 | ||
Tumor diameter ≥ 5cm | 137 | 62 | 1.12 (0.81–1.57) p = 0.490 | -- |
< 5cm | 185 | 79 | ||
Mucinous or signet ring | 34 | 19 | 1.35 (0.83–2.20) p = 0.224 | -- |
No | 288 | 122 | ||
Direct spread beyond muscularis propria | 271 | 126 | 2.02 (1.18–3.45) p = 0.010 | 2.04 (1.18–3.54) p = 0.011 |
No | 51 | 15 | ||
Apical node involved | 30 | 18 | 1.80 (1.08–3.00) p = 0.009 | 2.03 (1.22–3.39) p = 0.007 |
No | 292 | 123 | ||
≥ 4 nodes involved | 102 | 58 | 2.01 (1.43–2.81) p < 0.001 | -- |
No | 202 | 83 | ||
≥ 40% of nodes involved | 60 | 41 | 2.71 (1.88–3.91) p <0.001 | 2.52 (1.71–3.70) p <0.001 |
No | 262 | 100 | ||
Poorly differentiated | 66 | 42 | 2.12 (1.47–3.04) p <0.001 | -- |
No | 256 | 99 | ||
Venous invasion | 64 | 33 | 1.44 (0.98–2.13) p = 0.066 | -- |
No | 258 | 108 | ||
Free serosal surface involved | 76 | 47 | 2.36 (1.65–3.35) p < 0.001 | -- |
No | 246 | 94 | ||
Adjacent structure infiltrated | 23 | 17 | 3.16 (1.90–5.25) p < 0.001 | 2.88 (1.71–4.86) p <0.001 |
No | 299 | 124 | ||
Postoperative chemotherapy | 197 | 61 | 0.61 (0.26–0.51) p < 0.001 | 0.56 (0.37–0.85) p = 0.006 |
No | 125 | 80 | Â | Â |