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Table 3 Univariate and multivariate analysis in overall survival and progression-free survival

From: Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

Variable

Overall survival

Progression-free survival

5-year survival rate (%)

p-value (univariate)

p-value (multivariate)

Hazard ratio

95% CI

3-year survival rate (%)

p-value (univariate)

p-value (multivariate)

Hazard ratio

95% CI

Anatomical locations

          

 EHCC

38.1

0.837

   

48.3

0.395

   

 IHCC

28.0

    

28.2

    

 GB

34.5

    

45.6

    

Age

          

 ≤65 yr

39.9

0.095

   

48.4

0.707

   

 ≻65 yr

27.5

    

54.7

    

Gender

          

 Male

30.2

0.267

   

49.7

0.634

   

 Female

33.5

    

58.6

    

Resection

    

0.974 to 1.752

    

0.875 to 1.535

 R0

42.5

0.026

0.075

1.300

64.2

0.016

0.310

1.154

 R1 or R2

29.8

   

40.1

  

Tumor differentiation

    

0.881 to 1.593

    

0.729 to 1.307

 Well or moderate

47.3

0.017

0.251

0.190

55.2

0.008

0.845

0.971

 Poorly

7.8

   

39.6

   

Lymphatic permeation

    

1.057 to 7.629

    

1.212 to 10.72

 Yes

19.9

0.002

0.036

2.555

44.9

<0.001

0.016

3.139

 No

79.9

   

81.7

   

Vascular invasion

   

0.939

0.468 to 1.939

    

1.073 to 5.057

 Yes

20.5

0.011

0.862

 

40.2

<0.001

0.031

2.244

 No

58.7

   

74.8

  

Lymph nodes metastasis

   

0.977

0.552 to 1.706

    

0.517 to 4.534

 Positive

20.5

0.041

0.935

 

41.3

0.003

0.454

1.507

 Negative

44.0

   

63.2

   

Tumor stage

         

0.922 to 2.980

 I or II

38.2

0.051

   

60.1

0.003

0.088

1.685

 III or IV

29.5

    

26.8

   

LAT1

    

1.196 to 5.321

    

0.785 to 2.837

 High

20.3

<0.001

0.013

2.414

41.1

0.005

0.242

1.449

 Low

59.3

   

71.3

   

Ki-67

    

1.030 to 3.093

     

 High

29.6

0.021

0.038

1.781

49.2

0.192

   

 Low

36.2

   

53.6

    

p53

          

 Positive

21.3

0.119

   

54.1

0.831

   

 Negative

38.1

    

51.6

    

CD34

          

 High

28.6

0.349

   

51.1

0.696

   

 Low

42.8

    

52.2

    
  1. Abbreviation: 95% CI 95% confidence interval, EHCC Extrahepatic cholangiocarcinoma, IHCC Intrahepatic cholangiocarcinoma, GB Gallbladder carcinoma, CEA Carcinoembryonic antigen, LAT1 L-type amino acid transporter 1, Bold numbers Statistically significant difference.
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