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Table 5 Relationships between mutations and MSI patterns

From: Correlation of MLH1 and MGMTexpression and promoter methylation with genomic instability in patients with thyroid carcinoma

 Mutation status

N (%)

p

BRAF V600E*

      Positive

18/20 (90%)

1.000

     Negative

17/19 (89%)

RET/PTC*

      Positive

13/16 (81%)

0.642

     Negative

17/19 (89%)

Transitions (IDH1 + NRAS)

      Positive

9/11 (82%)

0.631

     Negative

22/25 (88%)

Point mutations (BRAF + IDH1 + NRAS)

      Positive

35/41 (85%)

1.000

     Negative

22/25 (88%)

  1. * Analysis performed only in the PTC group.
  2. Negative group comprises only samples without any of the alterations investigated.