The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

BMC Cancer

Table 3 Correlations among IL-6, IL-8, CXCR-2, SOCS-3 and VEGF H-score in the entire cohort (Results of Spearman correlation coefficient)

	IL-6	IL-8	CXCR2	SOCS-3	p-STAT-3	VEGF
IL-8	NS*
CXCR2	R = 0.2393, p = 0.0091***	R = 0.2989, p = 0.0010	NS
SOCS-3	NS	NS	NS	NS
p-STAT3	NS	NS	NS	NS	NS
VEGF	R = 0.2623, p = 0.0054	R = 0.1217, p = 0.0730	R = 0.3549, p = 0.0001	R = 0.2540, p = 0.0071**	NS	NS

(NS: not significant).
*IL-6 H-score was marginally higher in the cases positive for IL-8 (Mann Whitney U test, p = 0.0992).
**This correlation failed to attain statistical significance in a multivariate model, including the presence of metastasis, to which both were significantly related.
***This relationship lost its statistical significance in a multivariate regression model including VEGF.

ISSN: 1471-2407