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Table 2 Characterization of a subcohort used for tumoral RNA analyses, and comparison with the complete cohort

From: Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer

 

Complete cohort

Tumor subcohort

 

Individual variables

Total

n = 508

Total

n = 129

P

 

n

%

n

%

 

Age

     

  > 35 years-old

496

97.6

125

96.9

0.63

 ≤ 35 years-old

12

2.4

4

3.1

 

Family history

     

 No

400

87.7

85

85.9

0.61

 Yes

56

12.3

14

14.1

 

Histological type

     

 in situ

35

7.0

2

1.6

0.018

 Invasive

462

93.0

127

98.4

 

Tumor grade

     

 Grade 1

60

12.6

10

7.8

0.14

 Grade 2 or 3

416

87.4

117

90.7

 

Tumor size

     

 pT ≤ 2 cm

226

49.1

42

33.1

0.001

 pT > 2 cm

234

50.9

85

66.9

 

Lymph node status

     

 pN0 or pN1

432

85.0

99

76.7

0.024

 pN2 or pN3

76

15.0

30

23.3

 

ER/PR status

     

 Negative (both)

76

15.5

27

20.9

0.14

 Positive (either)

414

84.5

102

79.1

 

HER2 status

     

 Negative

378

83.8

102

81.0

0.45

 Positive

73

16.2

24

19.0

 

Biological classification

     

 Non triple negative

440

90.9

112

86.8

0.17

 Triple negative

44

9.1

17

13.2

 

EGFR genotypes

     

R497K

     

 Arg/Arg

308

61.0

82

64.1

0.380

 Arg/Lys

176

34.9

38

29.7

 Lys/Lys

21

4.2

8

6.3

 

(CA)n

     

 Short/Short

108

22.6

30

23.6

0.358

 Short/Long

230

48.2

68

53.5

 

 Long/Long

139

29.1

29

22.8

 
  1. Abbreviations: ER Estrogen receptor, PR Progesterone receptor, HER2 Human Epidermal groth factor Receptor 2. Statistically significant differences are presented in bold characters.
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BMC Cancer

ISSN: 1471-2407

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