Figure 4From: Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis The proposed model of MAT2A role on RCC development. The lower content of MAT2A level reduces the product of S-adenosylmethionine (SAMe) and then decreases the level of methylation, which leads to the reactivation of HO-1 expression to increase the cell proliferation and inhibit cell apoptosis.Back to article page