Table 1 Review of trials comparing participation in HPV self-sampling (SS) and reminder letter to attend for a Pap test
Study | Area | Eligibility | Intervention | Comparison | Device | Test, HPV+ | Participation | Follow-up | |
|---|---|---|---|---|---|---|---|---|---|
HPV SS | Pap arm | ||||||||
Sancho-Garnier [29] | France | 35-69 yrs; no Pap smear for ≥2 years; did not respond to first invitation | HPV SS kit* | Standard invitation | Dacron swab | Abbott real Time, 17.6% | 18.3% | 2% | 41% |
Szarewski [25] | UK | 25-65 yrs; ≥6 years overdue | HPV SS kit | Standard invitation | Cotton swab | HCII, 8.3% | 10.2% | 4.5% | 87.5% |
Wikstrom [22] | Sweden | 39-60 yrs; ≥6 years overdue | HPV SS kit* + 2nd reminder | Standard invitation | Qvintip | HCII, 6% | 39% | 9% | 98% |
Rossi [26] | Italy | 35-65 yrs; 3–5 months overdue | HPV SS kit | 2 control arms | Pantarhei device | HCII , 1 = 21.8%, 4 = 6.5% | 1 = 19.6%, 2 = 8.7% | 3 = 13.9%, 4 = 14.9% | 1 = 91% |
-Direct mail (1)* | -Standard recall (3) | ||||||||
-On demand (2) | -HPV at the clinic (4) | ||||||||
Virtanen [23] | Finland | 30-60 yrs; did not respond to primary invitation | HPV SS kit | Reminder letter | Delphi Screener | HCII | 29.8% | 26.2% | - |
Virtanen [24] | 30-60 years; did not respond to primary invitation | HPV SS kit* | Reminder letter | Delphi Screener | HCII, 12.3% | 32% | 26% | 86.6% | |
Gok [27] | Netherlands | 30-60 yrs; did not respond to invitation or 6 month reminder | HPV SS kit* | Second reminder letter* | Delphi screener | HCII, 10.3% | 26.6% | 16.4% | 90.4% |
Bais [28] | 30-50 yrs, did not respond to invitation or 6 month reminder | HPV SS kit | Second reminder letter | Viba-brush + collection tube | GP 5+/6+ PCR, 8% | 34.2% | 17.6% | 86% | |