Table 1 Correlation between nucleostemin expression and clinicopathological variables in surgically resected breast cancers
Variable | Number of cases (%) | |||
|---|---|---|---|---|
Nucleostemin expression | ||||
Total | Positive | Negative | P-value | |
(n = 220) | (n = 142) | (n = 78) | ||
Age | ||||
  Median (range) | 52 (30 ~ 82 y) | |||
  ≦52 | 109 | 71 (65) | 38 | 0.89 |
  >52 | 111 | 71 (64) | 40 | |
Tumor size | ||||
  <5.0 cm | 174 | 108 (62) | 66 | 0.21 |
  ≧5.0 cm | 42 | 31 (74) | 11 | |
  Unknown | 4 | 4(100) | 0 | |
Lymph node metastasis | ||||
  Negative | 115 | 70 (61) | 45 | 0.39 |
  Positive | 101 | 68 (67) | 33 | |
  Unknown | 4 | 4 (100) | 0 | |
Distant metastasis | ||||
  Negative | 209 | 134 (64) | 75 | 0.72 |
  Positive | 8 | 6 (75) | 2 | |
  Unknown | 3 | 2 (67) | 1 | |
Stage | ||||
  I or II | 179 | 111 (61) | 68 | 0.13 |
  III or IV | 37 | 28 (76) | 9 | |
  Unknown | 4 | 3 (75) | 1 | |
Nuclear grade | ||||
  1, 2 | 137 | 86 (63) | 51 | 0.48 |
  3 | 83 | 56 (67) | 27 | |
ER status | ||||
  Negative | 88 | 50 (57) | 38 | 0.050 |
  Positive | 132 | 92 (70) | 40 | |
PgR status | ||||
  Negative | 96 | 57 (59) | 39 | 0.16 |
  Positive | 124 | 85 (69) | 39 | |
HR (ER/PgR) status | ||||
  Negative | 66 | 40 (61) | 26 | 0.42 |
  Positive | 154 | 102 (66) | 52 | |
HER2 status | ||||
  Negative | 190 | 117 (62) | 73 | 0.02 |
  Positive | 30 | 25 (83) | 5 | |
p53 status | ||||
  Negative | 143 | 85 (59) | 58 | 0.03 |
  Positive | 77 | 57 (74) | 20 | |
Histological type | ||||
  Ductal | 191 | 125 (65) | 66 | 0.38 |
  Lobular | 10 | 5 (50) | 5 | |
  Mucinous | 6 | 6 (100) | 0 | |
  Tubular | 5 | 1 (20) | 4 | |
  Medullary | 3 | 2 (67) | 1 | |
  Other | 5 | 3 (60) | 2 | |