Figure 1

An overview of the measured signaling pathways and responses to treatment. A) A diagrammatic overview illustrating the cell signaling between the phosphoproteins measured (blue lettering), the treatments used (green lettering), and the inhibitors which were used on the LNCaP cells (red lines). B) Heatmap with hierarchical clustering illustrating the mean centered and variance scaled (z-score) changes in phosphoprotein values in response to varying treatments (see Methods), as well as survival values of LNCaP, PC3, or MDA-PCa-2b cells as measured via a MTT assay.