Clinicopathological analysis of thymic malignancies with a consistent retrospective database in a single institution: from Tokyo Metropolitan Cancer Center

Table 1 Characteristics of patients and tumors in patients with thymic malignancies

Characteristics		Thymoma		Thymic carcinoma
		n = 119	(%)	n = 68	(%)
Median age,	Years [range]	58 [26–81]	-	63 [14–83]	-
Gender
	Male	52	43.7	38	55.9
	Female	67	56.3	30	44.1
Histology
	Thymomas	119	100.0
	Type A	5	4.2
	Type B1	19	16.1
	Type B2	39	32.8
	Type B3	15	12.6
	Type AB	33	27.7
	Other subtypes or missing data of thymoma	8	6.7
	Thymic carcinomas			68	100.0
	Squamous cell carcinoma			46	67.6
	Mucoepidermoid carcinoma			5	7.4
	Lymphoepithelioma-like carcinoma			1	1.5
	Undifferentiated carcinoma			3	4.4
	Neuroendocrine carcinomas			11	16.2
	Small cell carcinoma			3	4.4
	LCNEC			2	2.9
	Carcinoid			6	8.8
	Not classified in WHO classification			2	2.9
Staging
	I	52	43.7	0	0
	II	31	26.1	6	8.8
	III	12	10.1	10	14.7
	IVa	18	15.1	16	23.5
	IVb	6	5.0	36	52.9
Complications
	Immunological abnormalities (overlapped)
	Myasthenia gravis	20	16.8	1	1.5
	Pure red cell aplasia	4	3.3
	Hypogammaglobulinemia	5	4.2
	Secondary malignancies	12	10.1	13	19.1
Initial treatment-intent of modalities
	Curative-intent treatment	116	97.5	43	63.2
	Surgery	109	91.6	30	44.1
	Surgery alone	89	74.8	10	14.7
	Surgery with perioperative treatment	20	16.8	20	29.4
	Radiotherapy	7	5.9	13	19.1
	Definitive radiotherapy alone	1	0.8	1	1.5
	Chmoradiotherapy (sequential/concurrent)	6	5.1	12	17.6
	Palliative-intent treatment	3	2.5	25	36.8
	Chemotherapy alone	2	1.7	24	35.3
	Best supportive care	1	0.8	1	1.5

ISSN: 1471-2407