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Table 4 Changes in nutritional and QoL parameters during HPN

From: A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

Characteristic

Baseline

Month 1

P

Baseline

Month 1

Month 2

P

Baseline

Month 1

Month 2

Month 3

P

 

N = 39

N = 22

N = 15

Nutritional Status

Weight (Kg)

61.5 (13.4)

63.1 (12.7)

0.03*

57.6 (14.1)

59.9 (13.8)

60.0 (12.4)

0.04*

61.1 (15.4)

63.4 (15.0)

63.6 (12.8)

65.9 (13.6)

0.04*

Albumin (g/DL)

2.8 (0.61)

3.1 (0.65)

0.03*

2.9 (0.66)

3.1 (0.59)

4.3 (5.1)

0.26

2.9 (0.69)

3.1 (0.65)

3.3 (0.44)

3.0 (0.57)

0.28

Performance Status

KPS

61.6 (11.2)

67.3 (10.7)

0.01*

63.2 (9.9)

70.0 (11.1)

73.2 (12.9)

0.01*

64.0 (11.2)

67.3 (11.0)

75.3 (14.6)

78.7 (11.2)

0.002*

QLQ-C30

General QoL

Global

38.6 (20.6)

46.3 (23.1)

0.98

37.1 (18.1)

51.5 (25.7)

49.2 (21.0)

0.02*

30.6 (15.9)

45.6 (27.1)

47.8 (23.4)

54.4 (24.8)

0.02*

General Function

Physical

59.6 (20.9)

62.4 (16.0)

0.39

56.4 (22.2)

66.1 (17.4)

70.1 (22.1)

0.02*

55.6 (25.6)

65.8 (20.1)

75.6 (23.2)

72.0 (21.8)

0.04*

Role

26.4 (25.3)

46.7 (33.1)

0.001*

29.5 (29.1)

49.2 (37.3)

55.3 (32.7)

0.01*

33.3 (32.7)

36.7 (36.3)

58.9 (31.1)

58.9 (39.8)

0.03*

Emotional

61.3 (22.8)

64.6 (26.3)

0.50

58.7 (22.9)

72.0 (24.5)

72.3 (25.9)

0.03*

59.4 (21.8)

67.2 (27.0)

67.2 (28.4)

72.8 (24.5)

0.19

Cognitive

65.7 (25.5)

68.1 (30.4)

0.57

66.7 (26.7)

73.5 (30.7)

77.3 (27.0)

0.10

64.4 (28.8)

67.8 (29.8)

78.9 (23.1)

64.4 (29.4)

0.09

Social

37.0 (27.6)

46.3 (29.6)

0.79

41.7 (32.8)

54.5 (30.9)

58.3 (27.1)

0.09

37.8 (33.0)

43.3 (27.3)

55.6 (30.6)

51.1 (34.2)

0.30

General Symptom

Fatigue

71.0 (20.8)

59.2 (26.8)

0.03*

73.2 (21.6)

54.0 (30.3)

50.5 (26.9)

0.002*

71.8 (23.3)

58.5 (34.2)

45.2 (28.3)

43.7 (30.1)

0.01*

Nausea/

52.3 (29.3)

37.0 (31.9)

0.03*

47.7 (26.7)

43.9 (34.7)

36.4 (32.3)

0.30

45.5 (31.1)

48.9 (34.8)

31.1 (30.1)

34.4 (30.5)

0.20

Vomiting

Pain

51.4 (35.5)

44.0 (29.6)

0.16

46.2 (37.8)

36.4 (31.1)

28.0 (29.3)

0.06

48.9 (38.0)

35.5 (35.6)

27.8 (31.9)

32.2 (31.5)

0.12

Dyspnea

25.9 (27.7)

19.4 (23.0)

0.21

21.2 (28.2)

16.7 (22.4)

16.7 (26.7)

0.74

31.1 (29.4)

17.8 (21.3)

17.8 (27.8)

20.0 (30.3)

0.41

Insomnia

47.2 (32.2)

45.4 (37.5)

0.77

45.4 (37.9)

40.9 (37.0)

28.8 (27.8)

0.18

51.1 (41.5)

48.9 (37.5)

26.7 (28.7)

33.3 (33.3)

0.09

Appetite Loss

67.6 (29.3)

46.3 (38.4)

0.004*

68.2 (28.1)

39.4 (38.0)

33.3 (39.8)

0.001*

64.4 (32.0)

48.9 (39.6)

31.1 (36.6)

33.3 (37.8)

0.02*

Constipation

37.0 (38.3)

22.2 (31.9)

0.03*

33.3 (38.5)

25.7 (29.0)

24.2 (34.4)

0.43

40.0 (42.2)

33.3 (30.9)

22.2 (32.5)

8.9 (26.6)

0.05*

Diarrhea

33.3 (37.4)

25.9 (31.0)

0.25

31.8 (39.1)

21.2 (26.3)

24.2 (37.3)

0.51

24.4 (36.6)

13.3 (16.9)

24.4 (36.6)

26.7 (40.2)

0.58

Financial

47.2 (39.3)

38.9 (32.4)

0.07

48.5 (42.0)

36.4 (37.0)

39.4 (40.7)

0.14

53.3 (41.4)

40.0 (36.1)

37.8 (39.6)

53.3 (39.4)

0.18

Problems

            
  1. Values in table are means.
  2. Values in parentheses are standard deviations.
  3. *P < = 0.05.
  4. QoL scores range from 0 to 100 and have no units.
  5. One-way repeated measures ANOVA used to analyze the data.
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