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Table 5 Longitudinal GEE analyses for QoL, nutritional and functional outcomes

From: A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

Dependent Variable

Univariate GEE β

P-Value

Multivariate GEE β

P-Value

 

95% CI

 

95% CI

 

Nutritional Status

Weight (Kg)

1.3 (0.32 to 2.2)

0.009*

1.2 (0.27 to 2.2)

0.01

Albumin (g/DL)

0.26 (−0.12 to 0.6)

0.18

0.25 (−0.1 to 0.6)

0.17

Performance Status

KPS

5.8 (3.8 to 7.8)

<0.001*

5.9 (4.0 to 7.8)

<0.001*

QLQ-C30

General QoL

    

Global

6.3 (2.9 to 9.6)

<0.001*

6.2 (2.7 to 9.6)

<0.001*

General Function

    

Physical

5.8 (1.8 to 9.9)

0.005*

5.7 (1.7 to 9.8)

0.006*

Role

12.2 (5.9 to 18.4)

<0.001*

12.1 (6.0 to 18.3)

<0.001*

Emotional

4.8 (1.2 to 8.3)

0.008*

4.7 (1.1 to 8.3)

0.01*

Cognitive

1.2 (−2.5 to 4.8)

0.53

1.1 (−2.5 to 4.8)

0.54

Social

6.2 (0.2 to 12.3)

0.04*

6.2 (0.1 to 12.2)

0.04*

General Symptom

    

Fatigue

−9.1 (−13.9 to −4.4)

<0.001*

−9.0 (−13.8 to −4.2)

<0.001*

Nausea/ Vomiting

−7.1 (−12.0 to −2.2)

0.005*

−7.0 (−11.6 to −2.5)

0.002*

Pain

−6.7 (−11.7 to −1.8)

0.008*

−6.7 (−11.7 to −1.7)

0.009*

Dyspnea

−3.7 (−9.6 to 2.2)

0.22

−3.6 (−9.6 to 2.3)

0.23

Insomnia

−6.5 (−12.2 to −0.9)

0.02*

−6.4 (−12.1 to −0.8)

0.02*

Appetite Loss

−13.7 (−19.2 to −8.1)

<0.001*

−13.4 (−18.8 to −8.1)

<0.001*

Constipation

−8.8 (−13.8 to −3.7)

0.001*

−8.7 (−13.6 to −3.7)

0.001*

Diarrhea

−0.87 (−8.0 to 6.2)

0.81

−0.6 (−7.5 to 6.3)

0.86

Financial Problems

−0.2 (−4.8 to 4.8)

0.99

−0.09 (−4.9 to 4.7)

0.97

  1. GEE β estimates in the table above reflect changes in the dependent variable for every 1 month increase in time.
  2. Multivariate β estimates were adjusted for age, gender and treatment history.
  3. *P < =0.05.
  4. QoL scores range from 0 to 100 and have no units.
  5. Longitudinal Generalized Estimating Equations used to analyze the data.