Characteristic | Luminal A (n = 119) | Luminal B Ki67+ (n = 52) | Luminal B HER2 + (22) | HER2 overexpression (16) | TNBC (46) | Statistics | P |
---|---|---|---|---|---|---|---|
Age (years) | 51.67 ± 10.10 | 50.88 ± 8.16 | 55.41 ± 8.98 | 52.13 ± 6.49 | 51.91 ± 10.90 | 0.896 | 0.467 |
Menopause | Â | Â | Â | Â | Â | 2.378 | 0.667 |
Postmenopausal | 56 | 24 | 14 | 7 | 22 | Â | Â |
Premenopausal | 63 | 28 | 8 | 9 | 24 | Â | Â |
Family history | Â | Â | Â | Â | Â | 2.075 | 0.722 |
No | 109 | 49 | 21 | 16 | 42 | Â | Â |
Yes | 10 | 3 | 1 | 0 | 4 | Â | Â |
Diameter | 2.15 ± 0.98 | 2.32 ± 0.94 | 2.43 ± 1.07 | 3.09 ± 1.49 | 2.50 ± 1.18 | 3.292 | 0.012 |
Quadrant | Â | Â | Â | Â | Â | 16.851 | 0.395 |
Areolar | 3 | 1 | 0 | 0 | 1 | Â | Â |
Inner upper | 28 | 8 | 0 | 2 | 7 | Â | Â |
Inner lower | 14 | 5 | 1 | 2 | 3 | Â | Â |
Outer lower | 21 | 11 | 3 | 2 | 6 | Â | Â |
Outer upper | 53 | 27 | 18 | 10 | 29 | Â | Â |
Enhancement patterns | Â | Â | Â | Â | Â | 59.901 | 0.000 |
Homogeneous | 40(33.6%) | 18(34.6%) | 7(31.8%) | 5(31.3%) | 12(26.1%) | Â | Â |
Heterogeneous | 71(59.7%) | 29(55.8%) | 8(36.4%) | 3(18.8%) | 10(21.7%) | Â | Â |
Peripherals | 8(6.7%) | 5(9.6%) | 7(31.8%) | 8(50.0%) | 24(52.2%) | Â | Â |
Difference of MVD (Edge - Center) | 3.12 ± 6.26 | 3.18 ± 7.95 | 7.61 ± 8.53 | 7.98 ± 8.97 | 10.23 ± 8.72 | 9.543 | 0.000 |
Grade of DMVD | Â | Â | Â | Â | Â | 42.300 | 0.000 |
Uniform distribution | 102(85.7%) | 44(84.6%) | 14(63.6%) | 6(37.5%) | 21(45.7%) | Â | Â |
Uneven distribution | 17(14.3%) | 8(15.4%) | 8(36.4%) | 10(62.5%) | 25(54.3%) | Â | Â |
Histological grade | Â | Â | Â | Â | Â | 30.927 | 0.000 |
I | 37(31.1%) | 16(30.8%) | 0(0%) | 1(6.3%) | 9(19.6%) | Â | Â |
II | 77(64.7%) | 29(55.8%) | 16(72.7%) | 10(62.5%) | 34(73.9%) | Â | Â |
III | 5(4.2%) | 7(13.5%) | 6(27.3%) | 5(31.3%) | 3(6.5%) | Â | Â |
Cancer thrombosis | Â | Â | Â | Â | Â | 7.806 | 0.099 |
Negative | 89 | 41 | 11 | 10 | 34 | Â | Â |
Positive | 30 | 11 | 11 | 6 | 12 | Â | Â |
Nodal metastasis | Â | Â | Â | Â | Â | 6.825 | 0.145 |
Negative | 60 | 24 | 8 | 3 | 23 | Â | Â |
Positive | 59 | 28 | 14 | 13 | 23 | Â | Â |
Number of metastatic nodes | 2.09 ± 4.16 | 2.94 ± 5.01 | 6.77 ± 9.63 | 11.88 ± 11.37 | 4.89 ± 9.70 | 9.167 | 0.000 |
Clinical stage | Â | Â | Â | Â | Â | 50.721 | 0.000 |
I | 33(27.7%) | 15(28.8%) | 1(4.5%) | 0(0%) | 10(21.7%) | Â | Â |
IIA | 38(31.9%) | 11(21.2%) | 10(45.5%) | 4(25.0%) | 13(28.3%) | Â | Â |
IIB | 39(32.8%) | 21(40.4%) | 4(18.2%) | 4(25.0%) | 16(34.8%) | Â | Â |
IIIA | 7(5.9%) | 3(5.8%) | 3(13.6%) | 3(18.8%) | 2(4.3%) | Â | Â |
IIIB | 1(0.8%) | 2(3.8%) | 2(9.1%) | 1(6.3%) | 1(2.2%) | Â | Â |
IIIC | 1(0.8%) | 0(0%) | 2(9.1%) | 4(25%) | 4(8.7%) | Â | Â |
IV | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | Â | Â |
P53 (%) | 27.76 ± 30.19 | 32.65 ± 34.17 | 41.55 ± 30.32 | 30.19 ± 32.23 | 35.50 ± 35.33 | 1.141 | 0.338 |
Operation | Â | Â | Â | Â | Â | 5.455 | 0.244 |
Mastectomy | 102 | 47 | 21 | 16 | 43 | Â | Â |
Tumorectomy | 17 | 5 | 1 | 0 | 3 | Â | Â |
Chemotherapy program | Â | Â | Â | Â | Â | 49.253 | 0.002 |
Not performed | 1(0.8%) | 0(0%) | 0(0%) | 0(0%) | 1(2.2%) | Â | Â |
CMF | 2(1.7%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | Â | Â |
CAF or AC | 42(35.3%) | 17(32.7%) | 2(9.1%) | 0(0%) | 11(23.9%) | Â | Â |
CEF or EC | 21(17.6%) | 12(23.1%) | 10(45.5%) | 5(31.3%) | 14(30.4%) | Â | Â |
T or TC or TP | 42(35.3%) | 15(28.8%) | 4(18.2%) | 2(12.5%) | 13(28.3%) | Â | Â |
TAC or A-T | 10(8.4%) | 8(15.4%) | 6(27.3%) | 9(56.3%) | 7(15.2%) | Â | Â |
Radiotherapy | Â | Â | Â | Â | Â | 6.682 | 0.154 |
Not performed | 67 | 27 | 10 | 4 | 27 | Â | Â |
Performed | 52 | 25 | 12 | 12 | 19 | Â | Â |
Endocrine therapy | Â | Â | Â | Â | Â | 262.436 | 0.000 |
Not performed | 0(0%) | 0(0%) | 0(0%) | 16(100%) | 46(100%) | Â | Â |
TAM | 75(63.0%) | 32(61.5%) | 12(54.5%) | 0(0%) | 0(0%) | Â | Â |
LHRH | 11(9.2%) | 7(13.5%) | 0(0%) | 0(0%) | 0(0%) | Â | Â |
AI | 33(27.7%) | 13(25.0%) | 10(45.5%) | 0(0%) | 0(0%) | Â | Â |
Targeted therapy | Â | Â | Â | Â | Â | 33.619 | 0.000 |
Not performed | 119(100%) | 52(100%) | 20(90.9%) | 13(81.3%) | 46(100%) | Â | Â |
Performed | 0(0%) | 0(0%) | 2(9.1%) | 3(18.8%) | 0(0%) | Â | Â |
Overall survival | 99.2% | 98.1% | 86.4% | 87.5% | 91.3% | 17.629 | 0.024 |
Event | 1 | 1 | 3 | 2 | 4 | Â | Â |
Deaths | 1 | 1 | 3 | 2 | 3 | Â | Â |
Lost to follow-up | 0 | 0 | 0 | 0 | 1 | Â | Â |
Median survival time | 54.0 | 48.0 | 36.0 | 29.4 | 35.2 | 31.845 | 0.000 |
Disease-free survival | 98.3% | 94.3% | 72.7% | 75.0% | 82.6% | 56.588 | 0.001 |
Event | 2 | 3 | 6 | 4 | 7 | Â | Â |
Local recurrence | 0 | 1 | 0 | 0 | 0 | Â | Â |
Contralateral breast cancer | 1 | 1 | 2 | 0 | 0 | Â | Â |
Lung metastasis | 0 | 0 | 0 | 1 | 1 | Â | Â |
Hepatic metastasis | 0 | 0 | 2 | 1 | 2 | Â | Â |
Brain metastasis | 0 | 0 | 0 | 1 | 2 | Â | Â |
Multi-organ | 1 | 1 | 2 | 1 | 2 | Â | Â |
Lost to Follow-up | 0 | 0 | 0 | 0 | 1 | Â | Â |
Disease-free survival | 54.0 | 48.0 | 35.4 | 22.5 | 31.7 | 59.248 | 0.000 |
Follow-up time | Â | Â | Â | Â | Â | 4.741 | 0.001 |
Median | 23.0 | 25.5 | 30.5 | 17.0 | 20.0 | Â | Â |
Range | 12-59 | 12-49 | 12-38 | 12-25 | 12-53 | Â | Â |