Table 1 Characteristics of the patients and measured biomarkers

Total

31 (100)

38 (100)

18 (100)

75 (100)

Median age [range] at diagnosis, years

60 [36–81]

57 [16–92]

66 [20–92]

59 [26–83]

0.248

Histologic subtype

Serous

22 (59)

12 (67)

49 (65)

Mucinous

15 (41)

6 (33)

8 (11)

Endometroid

15 (20)

Clear cell

3 (4)

Ang-1 (median, ng/mL)

23.1 [20.1-33.2]

29.4 [20.6-37.7]

24.0 [16.6-43.0]

31.0 [24.0-42.3]

0.035

Ang-2 (median, ng/mL)

1.5 [1.1-2.2]

1.9 [1.3-2.2]

1.6 [1.4-3.1]

2.7 [1.8-3.5]

<0.001

sVEGFR-1 (median, ng/mL)

0.13 [0.11-0.16]

0.11 [0.11-0.14]

0.11 [0.10-0.13]

0.13 [0.11-0.14]

0.062

sVEGFR-2 (median, ng/mL)

8.4 [6.6-11.7]

7.3 [6.4-8.4]

7.5 [6.3-8.7]

7.1 [5.8-8.3]

0.015

sVEGFR-3 (median, ng/mL)

30.7 [24.1-43.1]

31.3 [26.4-38.4]

30.0 [23.8-37.7]

31.2 [22.6-42.0]

0.888

VEGF-A (median, ng/mL)

0.31 [0.22-0.46]

0.24 [0.11-0.50]

0.28 [0.16-0.52]

0.43 [0.19-0.74]

0.033

VEGF-C (median, ng/mL)

7.4 [5.8-9.0]

8.0 [5.5-12.8]

9.8 [7.5-10.7]

7.0 [5.2-9.3]

0.129

VEGF-D (median, ng/mL)

0.29 [0.18-0.47]

0.33 [0.20-0.79]

0.58 [0.37-0.76]

0.46 [0.34-0.60]

0.002

VEGF-A/sVEGFR-2 (median, ng/mL)

0.04 [0.00-0.14]

0.03 [0.01-0.30]

0.04 [0.01-0.06]

0.05 [0.01-0.34]

0.011

Ang-2/VEGF-A (median, ng/mL)

4.9 [1.66-47.2]

8.4 [1.2-40.6]

6.8 [2.4-51.0]

7.6 [1.2-41.4]

0.673

Ang-2/sVEGFR-2

(median, ng/mL)

0.17 [0.07-0.69]

0.24 [0.12-0.63]

0.25 [0.12-0.67]

0.37 [0.15-1.5]

<0.001

CA125 (median, kU/l)

10 [7-16]

11 [8-18]

16 [9–82]

586 [124–1368]

<0.001