Skip to main content

Table 3 Selected highly expressed genes in grade III and IV astrocytomas.

From: Identification of astrocytoma associated genes including cell surface markers

Tag Sequence

Tumora

Inductionb

Gene

Gene Ontology

   

Anaplastic astrocytomas (Grade III)

 

AAGCCGAAGA

10

40

GFAP glial fibrillary acidic protein

Major intermediate filament protein of mature astrocytes

CTGGGGAGTG

8.1

22

VAPB VAMP associated protein B and C

Type IV membrane protein in plasma and intracellular vesicle membranes

GCAACAGCAA

80.9

19

SEC61G Sec61 gamma subunit

Endoplasmatic reticulum membrane protein, translocation

TTAATCTGAG

6.9

18

ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6, intra-cellular

ATCTTGTTAC

11

15

FN1 fibronectin 1

Extra-cellular matrix, cell adhesion, cell migration

GGAACAAACA

11.9

14

CD24

Plasma membrane, small cell lung carcinoma cluster 4 antigen

AGGGAGGGGC

32.9

14

GPX3 glutathione peroxidase 3

Extra-cellular, response to oxidative stress, glutathione metabolism

GTATGGGCCC

26.8

13

CHI3L1 chitinase 3-like 1

Cartilage glycoprotein

ACGAGGGGTG

71.4

12

BCAN, chondroitin sulfate proteoglycan

Cell adhesion

CACTTGAAAA

6.9

11

CALU calumenin

Endoplasmatic reticulum, calcium ion binding

GATAACTACA

6.7

11

IGFBP7

Extra-cellular, insulin-like growth factor binding protein 7

TCCTGTAAAG

6.8

11

CAV1 caveolin 1, 22 kDa

Plasma membrane, caveolae protein, integrin-mediated celladhesion, vesicular trafficking

GTCTTAAAGT

41.8

10

SOD2

Superoxide dismutase, mitochondrial, erythropoietin-mediated neuro protection through NF-kB

   

Glioblastomas (grade IV)

 

GTATGGGCCC

144.2

72

CHI3L1 chitinase 3-like 1

Cartilage glycoprotein

GACCACCTTT

17.3

69

MFAP2 microfibrillar-associated protein 2

Major antigen of elastin-associated microfibrils

ACCAAAAACC

115.8

49

COL1A1 collagen, type I, alpha 1

Extra-cellular matrix

AGTGGTGGCT

14.8

39

FMOD fibromodulin

Extra-cellular matrix, TGF beta receptor complex assembly

CTGGGGAGTG

13.2

35

VAPB VAMP associated protein B and C

Type IV membrane protein in plasma and intracellular vesicle membranes

ACATTCTTTT

38.2

34

GPNMB glycoprotein nmb

Transmembrane glycoprotein

ATCTTGTTAC

21.1

28

FN1 fibronectin 1

Extra-cellular matrix, cell adhesion, cell migration

GCAACAGCAA

97.9

23

SEC61G Sec61 gamma subunit

Endoplasmatic reticulum membrane protein, translocation

TCACCAAAAA

19.3

19

STAB1 stabilin 1

Cell adhesion, calcium ion binding

CACTTGAAAA

11.6

19

CALU calumenin

Endoplasmatic reticulum, calcium ion binding

TTTTCAAATA

15.4

15

T1A-2 lung type-I

Type I integral membrane glycoprotein

GTCTTTCTTG

24.4

14

RAB13

Cell adhesion, member RAS oncogene family

GGAAATGTCA

12.6

13

MMP2 matrix metalloproteinase

Extra-cellular matrix, calcium ion binding

GTACTAGTGT

23.8

12

CCL2 chemokine (C-C motif) ligand 2

Extra-cellular matrix, cell adhesion, signal transduction

AAGCTGTATA

16.7

12

TNC tenascin C (hexabrachion)

Extra-cellular matrix, cell adhesion

GTGCTAAGCG

10.8

11

COL6A2 collagen, type VI, alpha 2

Extra-cellular matrix

CATATCATTA

151.6

11

IGFBP7

Extra-cellular, insulin-like growth factor binding protein 7

AACACAGCCT

24.9

11

C4A complement component 4A

Extra-cellular matrix, complement pathway

  1. Highly expressed genes were selected with at least a ten fold over-expression when compared to normal neural tissue and a minimal expression level of at least 5 or 10 counts per 100,000 tags (in respectively grade III and IV tumors) in 30% of the corresponding tumor type. aAverage tag count count per individaul tunor SAGE library. bAverage induction factor.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us