Table 1 p16INK4a EXPRESSION IN NORMAL, DYSPLASTIC AND NEOPLASTIC EPITHELIAL CELLS OF CERVIX UTERI
From: Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells
STAINING* | ||||||
|---|---|---|---|---|---|---|
MATERIALS | number of samples | negative | poor | sporadic | focal | diffuse |
Normal epithelium (smears) | 6 | 6 (100) | - | - | - | - |
Cervical ectopia including | 37 | 34 (91,9) | 3 (8,1) | - | - | - |
C.e. + coilocytosis | 10 | 9 | 1 | - | - | - |
C.e. + condyloma | 2 | 1 | 1 | - | - | - |
Dysplasia: | ||||||
CINs I | 51 | 32 (62,7) | 12 (23,5) | 6 (11,8) | 1 (2,0) | - |
CINs II | 38 | 26 (68,4) | 7 (18,4) | 4 (10,5) | 1 (2,7) | - |
CINs III including cancer in situ | 24 | 8 (33,3) | 3 (12,5) | 7 (29,2) | 2 (8,3) | 4 (16,7) |
Invasive carcinomas including squamous cell carcinomas adenocarcinomas | 26 | 1 (3,8) | 1 (3,8) | 4 (15,5) | 7 (26,9) | 13 (50,0) |
Squamous cell carcinomas | 21 | 1 (4,8) | 1 (4,8) | 3 (14,3) | 6 (28,5) | 10 (47,6) |
Adenocarcinomas | 5 | - | - | 1 (20,0) | 1 (20,0) | 3 (60,0) |