Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation

BMC Cancer

Table 1 Differential gene expression between control cells and cells at different stages of mycoplasma-induced malignant transformation

Gene Class	Number of genes
	Screened	Expressed in control cells	Expressed and altered in cells following mycoplasmal infection
			1 week			11 weeks			18 weeks
			Expressed	Increased	Decreased	Expressed	Increased	Decreased	Expressed	Increased	Decreased
Apoptosis associated proteins	48	30	34	4	2	27	3	7	25	6	5
Cell adhesion receptors/proteins	100	61	60	6	1	61	9	10	69	12	3
Cell cycle associated proteins	45	34	31	2	4	26	2	9	35	2	5
Cell receptors (by activities)	162	74	90	16	5	90	26	16	70	9	14
Cell signaling, extracellular communication proteins	144	89	82	8	4	98	18	10	112	11	6
Cytoskeleton/motility proteins	59	39	41	4	3	37	8	8	51	6	7
DNA binding and chromatin proteins	44	23	29	5	1	29	6	1	31	8	0
Extracellular transport/carrier proteins	6	4	5	0	0	3	1	0	5	0	0
Extracellular matrix proteins	30	28	29	3	2	29	4	1	27	2	7
Functional unclassified	15	8	11	3	1	13	5	1	13	2	1
Intracellular transducers/effectors/modulators	253	155	158	20	6	149	26	28	201	32	10
Membrane channels, transporters and cell surface antigens	27	16	16	4	1	20	7	0	18	4	1
Metabolism-associated proteins	26	14	16	5	1	18	4	2	20	3	0
Oncogenes and tumor suppressors	65	43	46	3	1	41	6	7	53	8	2
Stress response proteins	39	24	22	1	1	21	3	2	26	2	3
Trafficking/targeting proteins	5	2	1	0	0	2	0	0	3	0	0
Transcription associated proteins	30	27	20	3	4	25	2	3	29	1	0
Translation, post-translation modification and protein turnover	87	65	64	5	6	58	8	9	74	7	5
Total	1185	736	755	92	43	748	138	114	862	115	69

ISSN: 1471-2407