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Table 3 Stratified analysis on association between the TS3'-UTR del6 polymorphism and risk of breast cancer

From: Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Variables

n (cases/controls)

TS3'-UTR del6

  

n (cases/controls)

  

aAdjusted OR (95% CI)

  
  

del6/del6

del6/ins6

ins6/ins6

del6/del6

del6/ins6

ins6/ins6

Age

≤ 48

158/195

80/98

69/76

9/21

1.00

1.11(0.70–1.76)

0.65(0.27–1.56)

> 48

274/278

114/118

139/125

21/35

1.00

1.08(0.74–1.58)

0.53(0.28–1.00)

Menopausal status

Premenopausal

197/210

93/105

90/82

14/23

1.00

1.22(0.80–1.86)

0.75(0.36–1.56)

Postmenopausal

235/263

101/111

118/119

16/33

1.00

1.01(0.68–1.50)

0.45(0.22–0.90)

Age at menarche

<16

239/152

103/70

117/69

19/13

1.00

1.06(0.68–1.64)

0.87(0.39–1.91)

≥16

193/321

91/146

91/132

11/43

1.00

1.13(0.77–1.65)

0.39(0.19–0.81)

bAge at first live birth

≤ 25

166/226

70/91

85/104

11/31

1.00

1.04(0.67–1.61)

0.47(0.22–1.03)

>25

253/234

116/118

120/95

17/21

1.00

1.24(0.82–1.87)

0.95(0.45–2.03)

Family history of cancer

No

319/378

143/173

155/165

21/40

1.00

1.07(0.77–1.48)

0.63(0.35–1.13)

Yes

113/95

51/43

53/36

9/16

1.00

1.27(0.69–2.35)

0.45(0.17–1.21)

  1. aAdjusted for the other covariates presented in this table in a logistic regression model for each stratum.
  2. b Age at first live birth information was available in 460 controls and 419 breast cancer cases.
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BMC Cancer

ISSN: 1471-2407

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