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Table 2 Polyamine levels, enzymatic activities and genes expression in normal and neoplastic colorectal tissues

From: Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer

 

Normal

Neoplastic

p

Putrescine

18.74 ± 3.1

50.87 ± 10.5

0.001

Spermidine

150.1 ± 10.6

302.2 ± 27.8

<0.0001

Spermine

387.3 ± 27.98

538.0 ± 41.7

0.003

Total polyamines

556.2 ± 39.9

891.0 ± 70.7

0.0002

ODC

21.2 ± 3.5

274.2 ± 70.9

<0.0001

SSAT

27.4 ± 3.8

40.4 ± 5.0

0.030

ODC mRNA

12.5 ± 2.0

20.7 ± 5.0

0.020

SSAT mRNA

2.7 ± 0.3

13.6 ± 1.5

<0.0001

PPARγ mRNA

0.3 ± 0.05

2.8 ± 0.5

<0.0001

  1. Polyamines are reported as nmol/g wet tissue. ODC activity is expressed as pmol 14CO2/h/mg of protein. SSAT activity is expressed as pmol N1-[14C] acetylspermidine/min/mg of protein. The relative mRNA levels are expressed as target gene/β-actin ratio. All data are presented as mean ± SEM (Wilcoxon matched pairs test).
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BMC Cancer

ISSN: 1471-2407

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