Figure 4

Activity and expression of uPA in tumor tissues andadjacent normal mucosaof colon and rectal cancer patients. (a) Casein-plasminogen zymography of representative specimens of colon tumor (CT) and the corresponding paired adjacent normal colonic mucosa (CN) from colon cancer patients, and rectal tumor (RT) and the corresponding paired adjacent normal rectal mucosa (RN) from rectal cancer patients. (b) Concentration of uPA in tumor tissues and adjacent normal colonic mucosa of colon and rectal cancer patients determined by ELISA. (c) Mean concentration (left panel) and fold increase (right panel) of uPA in tumor tissues compared with normal tissues. uPA levels are significantly increased in rectal cancer patients compared with colon cancer patients. *P < 0.05. ***P < 0.001.