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Table 2 Statistical analysis of MDR-1 expression and associated clinic-pathological findings in RCCs. The statistical evaluation of immunohistochemical results has been compared to clinical reports, pathological findings and follow-up data. No statistically significant correlation between MDR-1 expression and sex, age, tumour size, tumour stage and histological grade has been obtained.

From: Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: A five year follow-up analysis

Variables

N.

Score 1

Score 2

Score 3

MEAN ± SEM

Cases

30

19

7

4

 

Age

     

< 65 years

20

12

5

3

1,55 ± 0,17

> 65 years

10

7

2

1

1,40 ± 0,22

Sex

     

Male

21

14

4

3

1,48 ± 0,16

Female

9

5

3

1

1,56 ± 0,24

Tumour Size

     

≤ 7 cm

17

13

2

2

1,35 ± 0,17

> 7 cm

13

6

5

2

1,69 ± 0,21

Grading

     

G1

6

5

0

1

1,33 ± 0,33

G2

17

11

4

2

1,47 ± 0,17

G3–G4

7

3

3

1

1,71 ± 0,29

TNM Staging

     

I

(T1 N0 M0)

15

12

2

1

1,26 ± 0,15

II

(T2 N0 M0)

5

2

2

1

1,8 ± 0,37

III

(T1 N1 M1)

(T2 N1 M0)

(T3 N0 M0)

(T3 N1 M0)

7

4

2

1

1,57 ± 0,29

IV

(T4 N0 M0)

(T4 N1 M0)

(Any T Any N M+)

3

1

1

1

2,00 ± 0,57

  1. The statistical evaluation of immunohistochemical results has been compared to clinical reports, pathological findings and follow-up data. No statistically significant correlation between MDR-1 expression and sex, age, tumour size, tumour stage and histological grade has been obtained.
  2. SEM: standard error of mean; Score 1 (0–20% of positive cells); Score 2 (21–40% of positive cells); Score 3 (≥ 40% of positive cells).
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BMC Cancer

ISSN: 1471-2407

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