Table 1 CYP gene polymorphisms analysed
Gene | SNP | Details | Chr | Coordinate1 | Allele | A2B2 | Top strand |
|---|---|---|---|---|---|---|---|
CYP1A2 | rs2069522 | within 2kb 5' of mRNA | 15 | 72826286 | A | G | CAGATGGATGGGGAATCCAATAGAG [A/G]AACAGAGCATGTTTGAAGGCCATGA |
CYP1B1 | rs1800440 | coding N453S | 2 | 38209790 | A | G | TTCTTGGACAAGGAHGGCCTCATCA [A/G]CAAGGACCTGACCAGCAGAGTGATG |
rs1056836 | coding L432V | 2 | 38209854 | C | G | AAGTTCTCCGGGTTAGGCCACTTCA [C/G]TGGGTCATGATTCACAGACCACTGG | |
rs2617266 | intronic | 2 | 38214195 | A | G | GGCTGGTGCCCATGCTGGGGACAGA [A/G]AGGAGAAGGCGTGACACTCAGGGGT | |
rs2567206 | within 2kb 5' of mRNA | 2 | 38215182 | A | G | CGCTTCATCACAGCCACCTCCAATC [A/G]AGGCCGCACGGTGTCCCCAGAACCA | |
rs162558 | within 2kb 5' of mRNA | 2 | 38215730 | A | G | ACTTCAACCCGATAAAGTTCGCCGG [A/G]GCGCGGAGATTCGCCTCCTCCTGCC | |
rs49785885 | within 2kb 5' of mRNA | 2 | 38216383 | C | G | TGAGCTCCACTCGCGCTGCGAATCT [C/G]GTGCTATTATTGACCTGTTTACAGA | |
CYP3A4 | rs4986910 | coding M445T | 7 | 99003175 | A | G | TTTCATGTTCATGAGAGCAAACCTC [A/G]TGCCAATGCAGTTTCTGGGTCCACT |
rs2242480 | intronic | 7 | 99006117 | A | G | TTTTACCCAATAAGGTGAGTGGATG [A/G]TACATGGAGAAGGAGGGAGGAGGTG | |
rs2687116 | intronic | 7 | 99010594 | A | C | AATAAAGCAGTTATTTTTAAGAGAG [A/C]AAGATAAATAAAAGGAAATAGTAGT | |
rs4986907 | coding R162Q | 7 | 99012078 | A | G | GATGTGTTGGTGAGAAATCTGAGGC [A/G]GGAAGCAGAGACAGGCAAGCCTGTC | |
rs12721636 | 5' UTR | 7 | 99026417 | A | C | GGAAAGCTCCATGCACATAGCCCAG [A/C]AAAGAGCAACACAGAGCTGAAAGGA | |
rs2740574 | within 2kb 5' of mRNA | 7 | 99026747 | A | G | GAGGACAGCCATAGAGACAAGGGCA [A/G]GAGAGAGGCGATTTAATAGATTTTA | |
rs11773597 | within 2kb 5' of mRNA | 7 | 99027102 | C | G | CTGTCATGGCTCTGGTCCCTACCAG [C/G]GTGCTGTACACACAGTGGGCAACTA | |
CYP3A5 | rs15524 | 3' UTR | 7 | 99083850 | A | G | AGCTTTCTTGAAGACCAAAGTAGAA [A/G]TCCTTAGAATAACTCATTCTCCACT |
ss49785886 | coding T398N | 7 | 98894887 | A | C | AAAGGGTCAATGGTGGTGATTCCAA [A/C]TTATGCTCTTCACCATGACCCAAAG | |
rs776746 | intronic | 7 | 98915190 | A | G | CTTTAAAGAGCTCTTTTGTCTTTCA [A/G]TATCTCTTCCCTGTTTGGACCACAT | |
CYP11A1 | rs2073475 | within 2kb 5' of mRNA | 15 | 72448947 | A | G | TGCCCCACAACACTGGGGGAGGTGC [A/G]GAGGCCTGAACGGAAGTTGGGGTGG |
CYP17A1 | rs743572 | 5' UTR | 10 | 104587142 | A | G | GGTGCCGGCAGGCAAGATAGACAGC [A/G]GTGGAGTAGAAGAGCTGTGGCAACT |
CYP19A1 | rs10046 | intronic | 15 | 49290278 | A | G | CTACTGATGAGAAATGCTCCAGAGT [A/G]GGTACTGACCAGCCTTCTCTAGTGT |