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Table 2 Intestinal permeability before and during the therapy

From: Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

parameter

baseline (before therapy)

(mean ± SEM)

(95% CI)

(range)

after the first dose

(mean ± SEM)

(95% CI)

(range)

p (compared to baseline)

mean of subsequent measurements

(mean ± SEM)

(95% CI)

(range)

p (compared to baseline)

at the end of first or second cycle

(mean ± SEM)

(95% CI)

(range)

p (compared to baseline)

xylose (%)

17.1 ± 1.6

(13.9 – 20.2)

(0.8 – 45.3)

13.5 ± 1.5

(10.5 – 16.4)

(2.2 – 40.7)

0.03

16.2 ± 1.1

(14.0 – 18.5)

(4.2 – 35.5)

0.40

17.1 ± 1.6

(13.8 – 20.3)

(2.4 – 53.2)

0.41

mannitol (%)

11.4 ± 1.3

(8.8 – 14.0)

(0.5 – 34.2)

9.6 ± 0.9

(7.7 – 11.4)

(1.4 – 24.6)

0.21

13.1 ± 1.3

(10.4 – 15.9)

(2.0 – 36.2)

0.58

10.5 ± 1.0

(8.4 – 12.6)

(1.1 – 23.9)

0.16

sucrose (%)

0.41 ± 0.06

(0.30 – 0.52)

(0.05 – 1.40)

0.54 ± 0.07

(0.39 – 0.70)

(0.06 – 1.71)

0.06

0.47 ± 0.08

(0.30 – 0.64)

(0.08 – 2.51)

0.73

0.47 ± 0.09

(0.28 – 0.65)

(0.07 – 2.51)

0.43

lactulose (%)

0.57 ± 0.07

(0.42 – 0.73)

(0.06 – 2.40)

0.64 ± 0.07

(0.49 – 0.78)

(0.05 – 2.08)

0.46

0.56 ± 0.08

(0.41 – 0.72)

(0.12 – 2.19)

0.49

0.59 ± 0.10

(0.39 – 0.78)

(0.07 – 2.19)

0.30

lactulose/mannitol ratio

0.061 ± 0.006

(0.049 – 0.073)

(0.017 – 0.184)

0.101 ± 0.023

(0.055 – 0.147)

(0.010 – 0.770)

0.02

0.059 ± 0.006

(0.047 – 0.070)

(0.017 – 0.143)

0.54

0.058 ± 0.006

(0.045 – 0.071)

(0.009 – 0.136)

0.77

sucrose/mannitol ratio

0.038 ± 0.004

(0.030 – 0.046)

(0.008 – 0.098)

0.077 ± 0.017

(0.043 – 0.111)

(0.012 – 0.585)

0.004

0.048 ± 0.006

(0.035 – 0.061)

(0.008 – 0.154)

0.16

0.044 ± 0.006

(0.031 – 0.056)

(0.009 – 0.152)

0.37

lactulose/xylose ratio

0.039 ± 0.004

(0.030 – 0.047)

(0.014 – 0.139)

0.074 ± 0.016

(0.042 – 0.107)

(0.007 – 0.443)

0.004

0.041 ± 0.006

(0.027 – 0.054)

(0.008 – 0.166)

0.69

0.037 ± 0.006

(0.025 – 0.049)

(0.004 – 0.162)

0.90

sucrose/xylose ratio

0.024 ± 0.002

(0.019 – 0.029)

(0.004 – 0.061)

0.057 ± 0.011

(0.035 – 0.080)

(0.009 – 0.336)

0.001

0.034 ± 0.007

(0.020 – 0.048)

(0.004 – 0.186)

0.31

0.029 ± 0.006

(0.017 – 0.041)

(0.003 – 0.186)

0.74

  1. Shown is the mean ± standard error of the mean (SEM) of respective parameters. 95% confidence intervals (CI) of the mean are highlighted by the bold type, and range is indicated in the parenthesis below.
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BMC Cancer

ISSN: 1471-2407

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