Figure 3
From: Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
Histology of KCI-18 kidney tumors and lung metastases. Following implantation of KCI-18/IK cells in the kidney of nude mice; tumors were resected at different time points and processed for histology. Kidney tumor and lung sections were stained with H&E. Panel A: Development of high-grade carcinoma (arrowheads) with sinusoidal vascular pattern in the kidney (×10). Panel B: Kidney tumor morphology distinct from normal kidney tissue tubular morphology (×25). Panel C: Kidney tumor consisting of cells with large pleomorphic nuclei, prominent nucleoli and abundant eosinophilic cytoplasm (×100). Panel D: Metastatic nodules in lung (×25). Panels E, F: Kidney tumor sections immunostained for cytokeratin (E) and vimentin (F) showing positive cytoplasmic staining for both markers (×50). Magnifications (×-fold) are shown for each picture.