Table 2 Worst per-patient toxicity within the period of combined treatment (N = 50)
From: Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial
Type of toxicity | Patients (%) | ||||
|---|---|---|---|---|---|
| Â | 1 | 2 | 3 | 4 | 5 |
Allergy | 2 (4) | 2 (4) | 2 (4) | - | - |
Anemia | 18 (36) | 11 (22) | 2 (4) | - | - |
Leukopenia | - | 11 (22) | 7 (14) | 1 (2) | - |
Neutropenia | - | 5 (10) | 13 (26) | 10 (20) | - |
Febrile neutropenia | - | - | 4 (8) | - | - |
Platelets | 1 (2) | 2 (4) | - | - | Â |
Cardiac (LVEF decline) | 1 (2) | 2 (4) | - | - | - |
Renal | 1 (2) | 1 (2) | - | - | 1 (2) |
Fatigue | 12 (22) | 4 (8) | - | - | - |
Fever | 2 (4) | 1 (2) | - | - | - |
Hair loss | 1 (2) | - | - | - | - |
Skin | 3 (6) | 4 (8) | - | - | - |
Anorexia | 2 (4) | - | - | - | - |
Constipation | 12 (24) | 3 (6) | - | - | - |
Diarrhoea | 3 (6) | - | - | - | - |
Nausea | 5 (10) | 2 (4) | - | - | - |
Stomatitis | 3 (6) | - | - | - | - |
Vomiting | 4 (8) | - | - | - | - |
Liver | 1 (2) | 1 (2) | 1 (2) | - | - |
Sensorial neuropathy | 4 (8) | - | - | - | - |
Abdominal pain | 13 (26) | 1 (2) | 1 (2) | Â | Â |
RBC transfusion | - | - | 1 (2) | - | - |