Table 1 Correlation between histoclinical markers and Nectin-4 expression determined by IHC
From: Nectin-4 is a new histological and serological tumor associated marker for breast cancer
Characteristics |  | N° of patients (%) | P-value | |
|---|---|---|---|---|
| Â | Â | Nectin4 negative (N=39) 68.4% | Nectin4 positive (N=18) 31.6% | Â |
Age | <50 | 5 (14) | 4 (29) | NS |
| Â | >50 | 31 (86) | 10 (71) | Â |
Histological type | Ductal | 10 (26) | 16 (89) | <0.0001 |
| Â | Lobular | 29 (74) | 2 (11) | Â |
SBR grade | I | 9 (25) | 3 (21) | NS |
| Â | II | 17 (47) | 6 (43) | Â |
| Â | III | 10 (28) | 5 (36) | Â |
Axillary lymph node st. | Negative | 19 (53) | 6 (43) | NS |
| Â | Positive | 17 (47) | 8 (57) | Â |
EGFR | Negative | 31 (94) | 7 (54) | 0.0012 |
| Â | Positive | 2 (6) | 6 (46) | Â |
ERBB2 status | 0-1 | 34 (94) | 10 (71) | 0.0245 |
| Â | 2-3 | 2 (6) | 4 (29) | Â |
Ki67 | Negative | 23 (79) | 7 (50) | 0.05 |
| Â | Positive | 6 (21) | 7 (50) | Â |
P53 status | Negative | 33 (97) | 7 (50) | <0.0001 |
| Â | Positive | 1 (3) | 7 (50) | Â |
P-cadherin | Negative | 25 (74) | 4 (29) | 0.0029 |
| Â | Positive | 9 (26) | 11 (71) | Â |
BCL2 | Negative | 2 (6) | 6 (43) | 0.0025* |
| Â | Positive | 30 (94) | 8 (57) | Â |
Estrogen receptor st. | Negative | 0 (0) | 7 (50) | <0.0001* |
| Â | Positive | 37 (100) | 7 (50) | Â |
GATA3 | Negative | 3 (9) | 6 (60) | 0.0004* |
| Â | Positive | 31 (91) | 4 (40) | Â |
Progesterone receptor st. | Negative | 8 (24) | 8 (57) | 0.0247* |
| Â | Positive | 26 (76) | 6 (43) | Â |