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Table 2 Clinicopathological characteristics, LOH and gene expression variation in folds* for 16 tumor samples.

From: Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma

Sample (Patient) no.

Age (yrs)/Sex

Tumor classification

Metastasis

Tobacco use

LOH@ TSC1

LOH@ TSC2

TSC1 (D)

TSC2 (D)

AKT1 (U)

PIK3C2A (U)

PDPK1 (U)

RHEB (U)

FRAP1 (U)

RPS6KB1 (U)

RPS6 (U)

EIF4E (U)

EIF4EBP1(D)

PTEN (D)

54

40 M

T4N1M0

N/A

Yes

-

-

1.39

2.04

2.04

2.34

0.77

2.29

1.82

2.25

3.40

2.23

3.12

1.70

39

55 F

T4N1M0

Yes

Yes

-

-

1.77

1.95

4.04

2.47

2.33

1.92

2.68

3.34

2.67

3.01

0.98

1.44

19

48 F

T4N2bM0

No

Yes

-

-

1.93

3.57

3.29

1.63

1.57

2.12

2.21

2.93

2.01

2.07

1.45

2.04

15

55 F

T3N1M0

No

Yes

-

-

2.63

2.03

4.68

3.23

1.81

0.76

1.76

1.48

2.83

1.31

3.03

2.35

20

50 F

T4N1M0

Yes

Yes

-

-

1.98

2.03

1.46

1.65

0.65

0.85

0.92

1.34

1.50

1.98

3.02

1.87

8

50 F

T3N1M0

No

Yes

-

-

1.15

1.37

1.57

0.95

1.39

1.73

0.44

0.61

0.64

1.54

4.27

3.67

11

60 F

T4N1Mx

Yes

Yes

-

-

0.31

0.69

1.80

1.69

1.03

2.54

3.76

1.94

0.69

1.17

0.96

2.36

40

50 F

T2N1M0

Yes

Yes

+

-

2.33

1.48

1.75

2.16

1.90

2.22

2.82

6.25

1.83

4.22

2.06

1.60

50

40 M

T4N2bM0

Yes

Yes

-

-

1.20

2.98

1.34

0.58

1.43

1.22

1.25

2.45

2.69

1.50

3.67

1.35

52

70 M

ED

N/A

No

-

-

2.35

1.82

2.69

2.64

1.50

2.23

5.78

1.80

1.76

3.74

1.69

2.23

32

35 M

T4N0Mx

No

Yes

-

-

1.58

3.03

2.04

0.90

1.15

0.80

1.48

1.67

1.89

1.60

2.24

1.18

53

38 F

T2N0M0

No

Yes

+

-

7.92

1.51

3.68

2.88

2.59

2.78

1.19

2.32

1.21

2.13

2.77

1.99

55

40 F

T4N1M0

Yes

Yes

+

-

1.35

1.81

2.27

2.99

1.53

1.70

12.4

1.37

4.47

2.67

1.77

1.46

57

62 F

T1N0M0

Yes

Yes

-

-

1.40

2.39

2.26

4.50

8.26

2.95

2.24

5.05

1.80

2.32

2.17

0.50

59

70 F

T4N2bM0

Yes

Yes

-

+

2.38

1.30

1.48

2.80

1.92

1.67

1.38

0.67

1.66

1.70

5.07

1.23

60

40 F

T4aN1Mx

Yes

Yes

-

-

1.37

1.80

0.87

2.28

1.49

1.98

1.05

1.04

1.99

1.88

0.60

1.30

  1. * We defined the cutoff value for determining the upregulation or downregulation of a gene in a tumor sample as ≥ 1.8 fold difference in its expression between normal and tumor samples [3]. With this criterion, TSC1, TSC2, EIF4EBP1 and PTEN genes showed downregulation in 7/16, 11/16, 10/16 and 7/16 tumor samples, respectively. Whereas AKT1, PIK3C2A, PDPK1, RHEB, FRAP1, RPS6KB1, RPS6 and EIF4E showed upregulation in 10/16, 10/16, 6/16, 9/16, 8/16, 9/16, 10/16 and 10/16 tumor samples, respectively.
  2. Abbreviations: TNM, Tumor, Node, Metastasis; and ED, Epithelial dysplasia.
  3. 'Yes' in tobacco use refers to addiction to tobacco, bidi and cigarettes for at least 15–20 years. '+' denotes LOH found; '-' denotes no LOH; N/A, not applicable;
  4. (D)denotes downregulation of gene expression and (U)denotes upregulation of gene expression across 16 tumor samples.