Table 3 Functional classes of genes enriched in the Met library in comparison to the frequency within the whole set of predicted human genes
Functional Class (biological process) | Genes | Relative enrichment significance |
|---|---|---|
cell adhesion | ADAM10, CTGF, CTNNB1, CTNND1, FN1, ITGA6, ITGB1, ITGB8, LAMA4, NRCAM, SPP1, TGFBI, THBS2, TNFAIP6, HMCN1, CD164, NRP2, NRXN3, CD36 | O = 19a; E = 6.7b; R = 2.84c; P = 3.71E-05d |
cell-matrix adhesion | ITGA6, ITGB1, ITGB8, SPP1 | O = 4; E = 0.6; R = 6.67; P = 0.0030 |
regulation of cell adhesion | ADAM10, LAMA4, TGFBI, CD164 | O = 4; E = 0.4; R = 10; P = 0.00064 |
integrin-mediated signaling pathway | ADAM10, ITGA6, ITGB1, ITGB8 | O = 4; E = 0.57; R = 7.02; P = 0.0025 |
intracellular receptor-mediated signaling pathway | CTNNB1, EDD1, RB1, NCOA4 | O = 4; E = 0.47; R = 8.51; P = 0.0012 |
cell differentiation | ACVR1C, DCT, GPM6B, MGP, MITF, NRCAM, SERPINE2, SFRP1, SPP1, TYR, TYRP1, NRP2, NRXN3 | O = 13; E = 5.34; R = 2.43; P = 0.0027 |
cell motility | CTGF, FN1, ITGB1, LAMA4, NRCAM, SERPINE2, SPP1, NRP2, NRXN3 | O = 9; E = 2.42; R = 3.72; P = 0.00072 |
cell migration | FN1, ITGB1, LAMA4, NRCAM, SERPINE2, SPP1, NRP2, NRXN3 | O = 8; E = 1.04; R = 7.69; P = 9.41E-06 |
nucleocytoplasmic transport | ADAM10, KPNA1, NPM1, IPO9, G3BP2, THOC1 | O = 6; E = 1.25; R = 4.8; P = 0.0016 |
negative regulation of cell proliferation | GPNMB, FABP7, IL6, NPM1, CUL5, CD164 | O = 6; E = 1.59; R = 3.77; P = 0.0052 |
aromatic amino acid family metabolism | DCT, TDO2, TYR, TYRP1 | O = 4; E = 0.23; R = 17.39; P = 6.642E-05 |
aromatic compound metabolism | CPM, DCT, TDO2, TYR, TYRP1 | O = 5; E = 0.97; R = 5.15; P = 0.0028 |
cofactor biosynthesis | PBEF1, TMEM131, TPK1, ATP5A1, ATP6V1B2 | O = 5; E = 1.18; R = 4.24; P = 0.0066 |
coenzyme biosynthesis | PBEF1, TMEM131, TPK1, ATP5A1, ATP6V1B2 | O = 5; E = 1.04; R = 4.81; P = 0.0039 |
negative regulation of transcription | HMGB1, TRIM33, HBXAP, NKRF, RB1, ARID5B | O = 6; E = 1.72; R = 3.49; P = 0.0076 |
positive regulation of transcription | CTNNB1, ILF2, NFATC2, HBXAP, RB1, NCOA4 | O = 6; E = 1.19; R = 5.04; P = 0.0012 |
mRNA processing | DHX8, PABPC1, GRSF1, SFRS2, SNRPB2, SNRPG, G3BP2, THOC1 | O = 8; E = 2.13; R = 3.76; P = 0.0013 |
pigment metabolism | DCT, TYR, TYRP1 | O = 3; E = 0.25; R = 12; P = 0.0018 |