Table 6 Univariate and multivariate analyses according to microinvasion
From: Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
Odds ratio | 95% CI | P-value | Odds ratio | 95% CI | P-value | |
Necrosis (present vs. absent) | 5.56 | 1.84–20.91 | 0.0017 | 5.19 | 1.45–22.7 | 0.017 |
Apoptotic index (≧1000 of positive cells vs. < 1/1000) | 0.40 | 0.14–1.04 | 0.061 | 0.82 | 0.24–2.75 | 0.74 |
Ki-67 index (≧20% of positive cells vs. < 20%) | 0.44 | 0.15–1.18 | 0.10 | 0.89 | 0.24–3.24 | 0.86 |
Bcl-2 (positive vs. negative) | 2.57 | 0.93–7.95 | 0.071 | 3.49 | 1.04–13.3 | 0.051 |
Bax (positive vs. negative) | 10.92 | 2.02–203.9 | 0.0028 | 5.21 | 0.70–111.1 | 0.16 |
Survivin (positive vs. negative) | 4.76 | 1.57–17.9 | 0.0048 | 3.98 | 1.11–17.2 | 0.044 |