Prognostic parameters for recurrence of papillary thyroid microcarcinoma

BMC Cancer

Table 3 Univariate analyses of clinical recurrence with clinicopathological parameters in 293 patients with PTMC, according to surgical extent

Baseline characteristics	Patients with total or near-total thyroidectomy (n = 166)			Patients with hemi- or subtotal thyroidectomy (n = 127)			Overall (n = 293)
	HR	95% CI	P	HR	95% CI	P ^a	HR	95% CI	P
Age at operation
≤ 45 yrs	1.88	0.45–7.90	0.39	3.19	0.37–27.3	0.29	2.28	0.71–7.27	0.16
> 45 yrs	1.00	-	-	1.00	-	-	1.00	-	-
Gender
Men	5.92	1.41–24.8	0.02	4.6	0.83–25.4	0.96	5.22	1.74–15.6	0.003
Women	1.00	-	-	1.00	-	-	1.00	-	-
Tumor size
Per 1 mm increase	1.21	0.82–1.78	0.35	1.01	.0.68–1.51	0.96	1.11	0.85–1.45	0.45
Multifocality
Solitary tumor	1.48	0.35–6.19	0.59	0.25	0.05–1.36	0.11	0.87	0.29–2.59	0.8
Multifocal tumor	1.00	-	-	1.00	-	-	1.00	-	-
Extrathyroid extension
Absent	0.5	0.12–2.09	0.34	0.37	0.08–1.86	0.23	0.45	0.16–1.31	0.14
Present	1.00	-	-	1.00	-	-	1.00	-	-
Lymph node metastasis			0.08			0.83			0.049
pNx	0	NC	1	1.64	0.33–8.14	0.54	1.62	0.39–6.79	0.51
pN0	0	NC	1	0	NC	0.99	0	NC	0.99
pN1a^a	1.00	-	-	1.00	-	-	1.00	-	-
pN1b^b	8.25	1.66–40.9	0.01	N/A			5.25	1.60–17.3	0.51
Bilaterality
Unilateral tumor	0.71	0.17–2.97	0.64	N/A			0.81	0.23–2.90	0.74
Bilateral tumor	1.00	-	-				1.00	-	-
Remnant ablation
Not done	0	NC	1	N/A			N/A
Done	1.00	-	-

^a Metastases to level VI lymph nodes (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes), classified as N1a in the 2002 TNM staging.
^b Metastases to unilateral, bilateral, or contralateral cervical superior mediastinal lymph nodes, classified as N1b in the 2002 TNM staging.
Percent recurrence rates were given in parentheses; HR, hazard ration; CI, confidence interval; N/A, not applicable; INF, infinite; NC, cannot calculate

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